Urticaria pigmentosa is a rare dermatologic syndrome in humans, cats, and dogs. This report documents a case of canine urticaria pigmentosa-like disease with unusual features and no C-kit mutation.
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Urticaria pigmentosa-like skin disease in a domestic shorthair cat.
JFMS Open Rep
January 2019
Department of Clinical Medicine, University of Illinois Veterinary Teaching Hospital, Urbana, IL, USA.
Case Summary: A 14-month-old castrated male domestic shorthair cat presented with an 8 month history of severe pruritus, alopecia, papules and excoriations. Initial evaluation and treatment prior to referral included skin scrape, cytology, two strict food trials, dermatophyte culture, and bacterial culture and sensitivity, as well as antibiotic therapy, empiric treatment for mites, steroids and ciclosporin A (Atopica; Elanco). The cat was referred to the Dermatology and Otology Clinic at the University of Illinois Veterinary Teaching Hospital for further diagnostics and treatment.
View Article and Find Full Text PDFUrticaria pigmentosa-like disease in a dog.
Can Vet J
March 2015
Animal Allergy and Dermatology, 1100 Eden Way North, Chesapeake, Virginia 23320, USA (Pariser); University of Florida, College of Veterinary Medicine, PO Box 100126, Gainesville, Florida 32610, USA (Gram).
Urticaria pigmentosa is a rare dermatologic syndrome in humans, cats, and dogs. This report documents a case of canine urticaria pigmentosa-like disease with unusual features and no C-kit mutation.
View Article and Find Full Text PDFUnlabelled: PRESENTING SIGNS: Three Devon Rex cats were presented with multiple erythematous papules, occasionally associated with crusting and hyperpigmentation, with a linear distribution on the head, neck, chest and abdomen. One cat also had multifocal alopecia with hyperpigmentation on the dorsum.
Diagnosis And Treatment: Clinical and histopathological features were suggestive of papular eosinophilic/mastocytic dermatitis (urticaria pigmentosa-like dermatitis).
Differential diagnoses of systemic mastocytosis in routinely processed bone marrow biopsy specimens: a review.
Pathobiology
October 2010
Institute of Pathology, Ansbach, Germany.
Diagnosis of systemic mastocytosis (SM) is mainly based on the morphological demonstration of compact mast cell infiltrates in various tissue sites. In almost all patients such infiltrates are detected in the bone marrow. Reliable immunohistochemical markers for the diagnosis and grading of SM have been established, but various differential diagnoses including myeloproliferative neoplasms, basophilic and eosinophilic leukemias may be very difficult to delineate.
View Article and Find Full Text PDFAn unusual case of systemic mastocytosis associated with chronic lymphocytic leukaemia (SM-CLL).
J Clin Pathol
March 2006
Institute of Pathology, University of Lübeck, Germany.
Aims: Whereas focal accumulations of reactive lymphocytes around mast cell (MC) infiltrates are often seen in indolent systemic mastocytosis (ISM) involving the bone marrow, an association of systemic mastocytosis (SM) with malignant lymphoma/lymphatic leukaemia is very rare. This report contributes to the differential diagnosis of ISM by demonstrating that such lymphocytic aggregates may be neoplastic.
Methods: Biopsy specimens (bone marrow and gastrointestinal mucosa) of a 69 year old woman with mild blood lymphocytosis and a history of urticaria pigmentosa-like skin lesions that had disappeared a few years earlier, were investigated immunohistochemically using antibodies against CD3, CD5, CD20, CD23, CD25, CD34, CD117, chymase, and tryptase.
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