AI Article Synopsis
- Fibrinogen has been a widely used surgical sealant for years, but its use is limited by high costs and risks of infections from human plasma.
- A new type of fibrinogen developed from porcine (pig) plasma shows improved stability during sterilization and is more effective for controlling bleeding compared to a leading commercial product.
- This porcine-derived fibrinogen could be a more affordable and safer alternative, reducing the chances of transmitting human blood-borne pathogens.
Article Abstract
Fibrinogen has been used as surgical sealant in the clinical setting for decades. The application of human plasma-derived fibrinogen is limited due to high cost and the risk of prion and virus infection. We developed a novel arginine-formulated fibrinogen from cryoprecipitates of porcine plasma. This porcine-derived fibrinogen exhibited excellent stability during sterilization and better hemostatic efficacy than a leading commercial hemostatic product in a nonlethal hemorrhage model. Therefore, it has the potential to be more economical and readily available while having a decreased risk of human blood-borne pathogen transmission.
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| http://dx.doi.org/10.1007/s10856-015-5438-y | DOI Listing |
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