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Synergism between exposure to mercury and use of iodine supplements on thyroid hormones in pregnant women. | LitMetric

AI Article Synopsis

  • - The study aimed to investigate how mercury exposure affects thyroid hormone levels (TSH, TT3, FT4) in pregnant women and whether iodine intake modifies this effect.
  • - A total of 1,407 pregnant women were analyzed, with mercury levels measured in cord blood and thyroid hormones in serum at around 13 weeks of pregnancy, using linear regression to assess these associations.
  • - Results indicated a marginally significant negative relationship between mercury and TT3 levels, especially among women taking iodine supplements, raising potential public health concerns that warrant further investigation.

Article Abstract

Objective: To evaluate the association between mercury exposure and thyroid-stimulating hormone (TSH), total triiodothyronine (TT3) and free thyroxine (FT4) levels during pregnancy as well as to explore if there is any synergic action between mercury and intake of iodine from different sources.

Methods: The study population was 1407 pregnant women participating in the Spanish INMA birth cohort study. Total mercury concentrations were analyzed in cord blood. Thyroid hormones (THs) were measured in serum samples collected at 13.2±1.5 weeks of gestation. The association between mercury and TH levels was evaluated with multivariate linear regression models. Effect modification caused by iodine intake from supplements and diet was also evaluated.

Results: The geometric means of TSH, TT3, FT4 and mercury were 1.1μU/L, 2.4nmol/L, 10.5pmol/L and 7.7μg/L, respectively. Mercury levels were marginally significantly associated with TT3 (β: -0.05; 95%CI: -0.10, 0.01), but were neither associated with TSH nor FT4. The inverse association between mercury and TT3 levels was stronger among the iodine supplement consumers (-0.08; 95%CI: -0.15, -0.02, interaction p-value=0.07). The association with FT4 followed the same pattern, albeit not significant.

Conclusion: Prenatal mercury exposure was inversely associated with TT3 levels among women who took iodine supplements during pregnancy. These results could be of public health concern, although further research is needed.

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Source
http://dx.doi.org/10.1016/j.envres.2015.02.026DOI Listing

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