AI Article Synopsis
- - This study tested how well nebivolol can prevent oxidative stress caused by high homocysteine levels (hHcy) in various tissues of rats, including the brain, heart, liver, and kidneys, as well as its effects on the thoracic aorta.
- - Researchers divided 24 male rats into four groups to measure changes in specific biochemical markers and structural changes in the aorta after inducing hHcy with L-methionine and treating with nebivolol.
- - Results showed that nebivolol lowered homocysteine levels, reduced harmful oxidative markers, improved antioxidant levels in several tissues, and positively influenced the structural changes in the aorta, suggesting its potential therapeutic role in conditions
Article Abstract
Objective: This study investigated the prophylactic effect of nebivolol against hyper-homocysteinaemia (hHcy) induced oxidative stress in brain, heart, liver and kidney tissues and histomorphometric changes in the thoracic aorta.
Methods: Twenty-four adult male Wistar rats were divided into a control, nebivolol, hHcy and nebivolol+hHcy group. hHcy was induced by oral administration of L-methionine (1 g/kg/day) for 28 days. 10 mg/kg/day nebivolol was administered orally for 28 days. Malondialdehyde (MDA) and glutathione (GSH) levels and catalase (CAT) and superoxide dismutase (SOD) activities in the tissues were determined. The total cross-sectional area (TCSA), luminal cross-sectional area (LCSA) and intima-media thickness (IMT) were measured in the thoracic aorta.
Results: Homocysteine (Hcy) levels were lower in the nebivolol+hHcy group than in the hHcy group. Nebivolol treatment significantly decreased high MDA levels in the brain, heart and liver tissues. The level of GSH was higher in the brain, heart and kidney tissues of the nebivolol+hHcy group (P<0.001). The activity of CAT increased only in the kidney tissue of the nebivolol+hHcy group (P<0.01), and the activity of SOD was significantly increased in all the tissues in this group. Increased TCSA and IMT in the nebivolol+hHcy group were significantly decreased after nebivolol administration. The LCSA was significantly higher in the hHcy group than the control group, probably due to outward vascular remodelling.
Conclusion: Nebivolol treatment may be useful in different clinical scenarios where hHcy affects physiopathological pathways.
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| http://dx.doi.org/10.1016/j.atherosclerosis.2015.02.054 | DOI Listing |
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