AI Article Synopsis
- Early diagnosis and treatment of central diabetes insipidus (CDI) in neonates is crucial to prevent serious health issues.
- A case study showed that the new oral desmopressin lyophilisate (Minirin Melt®) can be used in infants diagnosed with CDI, with varying initial doses leading to different pharmacokinetic profiles.
- Minirin Melt® was found to be effective and well-tolerated in infants, highlighting its potential as a safe treatment option for CDI.
Article Abstract
Introduction: In neonates and small infants, early diagnosis of central diabetes insipidus (CDI) and treatment with desmopressin in low doses (avoiding severe hypo- or hypernatremia) are important to prevent associated high morbidity and mortality in this particular age group.
Case Presentation: We described pharmacokinetic and pharmacodynamic results of the use of recently launched oral desmopressin lyophilisate (Minirin Melt®) in two infants with CDI, diagnosed at the age of 12 and 62 days, respectively. We observed that a starting dose of 60 μg of Minirin Melt® in the first case resulted in a pharmacokinetic profile largely exceeding the reference frame observed in children with nocturnal enuresis, while a dose of 15 μg in the second case resulted in acceptable concentrations. After initial dose adjustments, administration of sublingual lyophilisate resulted in rather stable serum sodium concentrations.
Conclusions: Using Minirin Melt® in infants with CDI appears to be effective, easy to use and well tolerated.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338649 | PMC |
| http://dx.doi.org/10.5812/ijem.16120 | DOI Listing |
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