AI Article Synopsis
- Cerebral hemiatrophy is a common childhood condition that can lead to seizures, hemiparesis, and intellectual disabilities.
- In a study of untreated patients, two groups (acquired and congenital hemiatrophy syndromes) were analyzed for seizure frequency over 6 months, with significant reductions observed in both groups.
- The results indicated that congenital hemiatrophy patients experienced better seizure control compared to those with acquired hemiconvulsion, and specific factors like hemispheric ratio helped predict seizure recurrences.
Article Abstract
Purpose: Cerebral hemiatrophy is a common childhood disease. It clinically manifests with seizures, hemiparesis and mental retardation.
Materials And Methods: In this prospective study, previously untreated patients with seizures and cerebral hemiatrophy were recruited. Cerebral hemiatrophy was diagnosed on the basis of hemispheric ratio. Patients with acquired hemiconvulsion, hemiplegia, and epilepsy (HHE) syndrome were included in group A. Group B included patients with congenital HHE syndrome. Patients were followed up for 6 months for seizure recurrence.
Results: Out of 42 patients 26 were in group A and 16 were in group B. After 6 months, there was significant reduction in seizure frequency (P < 0.0001) in both the groups. At least 50% reduction in seizure frequency was noted in all the patients. Complete seizure freedom was observed in 15 (35.7%) patients. Seizure recurrences were significantly higher (P = 0.008) in group A. On univariate analysis, predictors of seizure recurrences were history of febrile seizures (P = 0.013), hippocampal sclerosis (P = 0.001), thalamic atrophy (P = 0.001), basal ganglia atrophy (P = 0.001), cerebellar atrophy (P = 0.01), ventricular dilatation (P = 0.001), epileptiform discharges at presentation (P = 0.023), complex partial seizures (P = 0.006) and status epilepticus (P = 0.02). On multivariate analysis, hemispheric ratio was the only significant factor for seizure recurrence.
Conclusion: Patients with congenital hemiatrophy had better seizure control than that in patients with HHE syndrome.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350212 | PMC |
| http://dx.doi.org/10.4103/0972-2327.144296 | DOI Listing |
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