AI Article Synopsis
- Immune cells, like natural killer (NK) cells, help eliminate transformed cells through a process called immunosurveillance, but tumor cells can evade this by shedding ligands that desensitize NK and T cells.
- Research shows that a soluble form of MULT1, a ligand that activates the NKG2D receptor on NK cells, actually stimulates NK cell activation and helps reject tumors in mice.
- This study challenges the belief that soluble ligands are always inhibitory and indicates that using soluble MULT1 could be a promising new strategy for cancer immunotherapy.
Article Abstract
Immune cells, including natural killer (NK) cells, recognize transformed cells and eliminate them in a process termed immunosurveillance. It is thought that tumor cells evade immunosurveillance by shedding membrane ligands that bind to the NKG2D-activating receptor on NK cells and/or T cells, and desensitize these cells. In contrast, we show that in mice, a shed form of MULT1, a high-affinity NKG2D ligand, causes NK cell activation and tumor rejection. Recombinant soluble MULT1 stimulated tumor rejection in mice. Soluble MULT1 functions, at least in part, by competitively reversing a global desensitization of NK cells imposed by engagement of membrane NKG2D ligands on tumor-associated cells, such as myeloid cells. The results overturn conventional wisdom that soluble ligands are always inhibitory and suggest a new approach for cancer immunotherapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856222 | PMC |
| http://dx.doi.org/10.1126/science.1258867 | DOI Listing |
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