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Single-centre, double-blinded, randomised placebo-controlled trial to determine the effect of a 12-week home-based programme of footplate neuromuscular electrical stimulation on walking capacity in people with peripheral artery disease: a protocol for the Foot-PAD trial.
BMJ Open
January 2025
College of Medicine and Dentistry, James Cook University, Queensland Research Centre for Peripheral Vascular Disease, Townsville, Queensland, Australia.
Introduction: Patients with peripheral artery disease (PAD) can experience intermittent claudication, which limits walking capacity and the ability to undertake daily activities. While exercise therapy is an established way to improve walking capacity in people with PAD, it is not feasible in all patients. Neuromuscular electrical stimulation (NMES) provides a way to passively induce repeated muscle contractions and has been widely used as a therapy for chronic conditions that limit functional capacity.
View Article and Find Full Text PDFA High-Precision Micro-Roll Forming Facility for Fuel Cell Metal Bipolar Plate Production.
Micromachines (Basel)
January 2025
School of Engineering, Deakin University, 75 Pigdons Rd., Waurn Ponds, Geelong, VIC 3216, Australia.
The metal bipolar plate is a critical component of the hydrogen fuel cell stack used in proton exchange membrane fuel cells. Bipolar plates must have high accuracy micro-channels with a high aspect ratio () between the channel depth and the half periodic width to achieve optimal cell performance. Conventional forming methods, such as micro-stamping, hydroforming, and rubber pad forming, cannot achieve these high ARs given that in these processes, material deformation is dominated by stretch deformation.
View Article and Find Full Text PDFAssociation Between ABO Blood Group, Peripheral Artery Disease Lesion Severity, and Coronary Artery Disease Coexistence.
Ann Vasc Surg
January 2025
Dicle University School of Medicine, Department of Cardiology, Diyarbakır, Turkey.
Objectives: This study aims to investigate the relationship between ABO blood groups and the severity of Peripheral Artery Disease (PAD) lesions, the coexistence of Coronary Artery Disease (CAD) with PAD, and to identify which blood groups may be more predisposed to these conditions.
Methods: This study, which has a single-center and retrospective design, includes 305 patients diagnosed with Peripheral Artery Disease (PAD) between 2015 and 2021. The patients were selected from those with at least 50% stenosis detected by computed tomography (CT) angiography.
DisCo P-ad: Distance-Correlation-Based -Value Adjustment Enhances Multiple Testing Corrections for Metabolomics.
Metabolites
January 2025
Department of Biostatistics & Informatics, Colorado School of Public Heath, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Background: Due to scientific advancements in high-throughput data production technologies, omics studies, such as genomics and metabolomics, often give rise to numerous measurements per sample/subject containing several noisy variables that potentially cloud the true signals relevant to the desired study outcome(s). Therefore, correcting for multiple testing is critical while performing any statistical test of significance to minimize the chances of false or missed discoveries. Such correction practice is commonplace in genome-wide association studies (GWAS) but is also becoming increasingly relevant to metabolome-wide association studies (MWAS).
View Article and Find Full Text PDFBionic Modeling Study on the Landing Mechanism of Flapping Wing Robot Based on the Thoracic Legs of Purple Stem Beetle, .
Biomimetics (Basel)
January 2025
Robotics and Microsystems Center, College of Mechanical and Electrical Engineering, Soochow University, Suzhou 215021, China.
Flapping wing micro aerial vehicles (FWMAVs) are recognized for their significant potential in military and civilian applications, such as military reconnaissance, environmental monitoring, and disaster rescue. However, the lack of takeoff and landing capabilities, particularly in landing behavior, greatly limits their adaptability to the environment during tasks. In this paper, the purple stem beetle (), a natural flying insect, was chosen as the bionic research object.
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