AI Article Synopsis
- - The study aimed to investigate the role of P-selectin, a molecule involved in cell adhesion, in the risk of developing coronary heart disease (CHD) among a diverse population.
- - Researchers analyzed data from the Multi-Ethnic Study of Atherosclerosis (MESA), focusing on factors like obesity, blood pressure, and cholesterol levels and found that higher P-selectin levels correlated with increased risk of atherosclerosis and CHD, especially in non-Hispanic whites.
- - Results showed significant differences in P-selectin levels based on ethnicity and gender, highlighting the complex relationship between this molecule and CHD risk factors across different populations.
Article Abstract
Objective: P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population.
Methods: Data from the Multi-Ethnic Study of Atherosclerosis (MESA), including 1628 African, 702 Chinese, 2393 non-Hispanic white, and 1302 Hispanic Americans, were used to investigate the association of plasma P-selectin with CHD risk factors, coronary artery calcium (CAC), intima-media thickness, and CHD. Regression models were used to investigate the association between P-selectin and risk factors, Tobit model for CAC, and Cox regression for CHD events.
Results: Mean levels of P-selectin differed by ethnicity and were higher in men (P<0.001). For all ethnic groups, P-selectin was positively associated with measures of adiposity, blood pressure, current smoking, LDL, and triglycerides and inversely with HDL. A significant ethnic interaction was observed for the association of P-selectin and prevalent diabetes; however, P-selectin was positively associated with HbA1c in all groups. Higher P-selectin levels were associated with greater prevalence of CAC. Over 10.1 years of follow-up, there were 335 incident CHD events. There was a positive linear association between P-selectin levels and rate of incident CHD after adjustment for traditional risk factors. However, association was only significant in non-Hispanic white Americans (HR: 1.81, 95% CI 1.07 to 3.07, P=0.027).
Conclusion: We observed ethnic heterogeneity in the association of P-selectin and risk of CHD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397161 | PMC |
| http://dx.doi.org/10.1016/j.atherosclerosis.2015.02.036 | DOI Listing |
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