AI Article Synopsis
- Toll-like receptors (TLRs) are sensitive to oxidative stress and are key in the cellular response to imbalances in pro-oxidants and antioxidants, which are linked to breast diseases.
- Decreases in trace elements (selenium, copper, zinc, magnesium, iron) and increases in malondialdehyde (a marker for lipid damage) correlate with reduced TLR activity in patients with benign breast diseases and breast cancer.
- The study findings indicate that patients with benign breast diseases have a higher likelihood of developing breast cancer, as suggested by the odds ratio associated with lipid damage.
Article Abstract
Toll-like receptors are recognized as redox sensitive receptor proteins and have been implicated in cellular response to oxidative stress. Altered pro-oxidant-antioxidant balance leads to an increased oxidative damage and consequently play an important role in breast diseases. The study was designed to access the oxidative stress status by quantification of byproducts generated during lipid peroxidation and inadequate trace elements during oxidative damage and its effects on the toll like receptor (TLR) activity in patients of breast diseases. Decreased levels of selenium, copper, zinc, magnesium and iron with elevated levels of malondialdehyde (marker of lipid peroxidation) were accompanied by decreased TLR activity in patients of benign breast diseases as well as breast carcinoma. A similar pattern was observed with the advancement of disease and its subsequent progression in breast carcinoma patients. Results of multinomial regression analysis suggest benign breast disease patients are at higher risk of developing breast cancer with high odds ratio of lipid damage.
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| http://dx.doi.org/10.1016/j.jtemb.2014.12.003 | DOI Listing |
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