AI Article Synopsis
Article Abstract
Background: Untreated syphilis during pregnancy is associated with spontaneous abortion, stillbirth, prematurity and infant mortality. Syphilis may facilitate HIV transmission, which is especially concerning in low- and middle-income countries where both diseases are common.
Methods: We performed an analysis of data available from NICHD/HPTN 040 (P1043), a study focused on the prevention of intrapartum HIV transmission to 1684 infants born to 1664 untreated HIV-infected women. This analysis evaluates risk factors and outcomes associated with a syphilis diagnosis in this cohort of HIV-infected women and their infants.
Results: Approximately, 10% of women (n=171) enrolled had serological evidence of syphilis without adequate treatment documented and 1.4% infants (n=24) were dually HIV and syphilis infected. Multivariate logistic analysis showed that compared with HIV-infected women, co-infected women were significantly more likely to self-identify as non-white (adjusted odds ratio [AOR] 2.5, 95% CI: 1.5-4.2), to consume alcohol during pregnancy (AOR 1.5, 95% CI: 1.1-2.1) and to transmit HIV to their infants (AOR 2.1, 95% CI: 1.3-3.4), with 88% of HIV infections being acquired in utero. As compared with HIV-infected or HIV-exposed infants, co-infected infants were significantly more likely to be born to mothers with venereal disease research laboratory titers≥1:16 (AOR 3, 95% CI: 1.1-8.2) and higher viral loads (AOR 1.5, 95% CI: 1.1-1.9). Of 6 newborns with symptomatic syphilis, 2 expired shortly after birth, and 2 were HIV-infected.
Conclusion: Syphilis continues to be a common co-infection in HIV-infected women and can facilitate in utero transmission of HIV to infants. Most infants are asymptomatic at birth, but those with symptoms have high mortality rates.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352722 | PMC |
| http://dx.doi.org/10.1097/INF.0000000000000578 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anthropometric measurements as predictors of nutritional status in black South African women during pregnancy.
J Obstet Gynaecol Res
January 2025
Department of Medical Biochemistry, University of KwaZulu-Natal, Durban, South Africa.
Background: Nutritional risk assessment is an essential component of primary health care screening, especially for pregnant women. The aim of this study was to investigate the relationship between maternal body mass index (BMI) and maternal anthropometric measurements in black South African pregnant women, both with and without human immunodeficiency virus (HIV).
Materials And Methods: A cross-sectional observational study design was used.
Correlation between HPV-16 integration status and cervical intraepithelial neoplasia and cervical cancer in patients infected with HIV.
Bull Cancer
December 2024
Department of Intensive Care Unit, Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, 510030 Guangzhou, China. Electronic address:
Article Synopsis
- The research included 96 patients, with a focus on 43 individuals diagnosed with both HIV and cervical cancer or precancerous conditions, analyzing RNA from their tissues to determine HPV expression.
- Results showed HIV-positive patients had a higher rate of integrated HPV-16 infections linked to lower CD4+ T cell counts, suggesting that HIV-related immunosuppression increases the progression of cervical lesions, emphasizing the need for better screening and treatment for HIV-positive women.
Spatial transcriptomics and immune cell profiling of the host ectocervical landscape of HIV infected Kenyan sex working women.
Front Immunol
December 2024
Department of Medicine Solna, Division of Infectious Diseases, Karolinska Institutet, Division of Infectious Diseases, Karolinska University Hospital, Center for Molecular Medicine, Stockholm, Sweden.
Introduction: Chronic immune activation is a hallmark of human immunodeficiency virus (HIV) infection that significantly impacts disease pathogenesis. However, in-depth studies characterizing the immunological landscape of the ectocervix during chronic HIV infection remain scarce despite the importance of this tissue site for HIV transmission.
Methods: Ectocervical tissue samples were obtained from antiretroviral-naïve HIV-seropositive and -seronegative Kenyan female sex workers.
[Epidemic characteristics of HIV-infected people among Chinese and Burmese in Dehong Dai and Jingpo Autonomous Prefecture of Yunnan Province, 2000-2023].
Zhonghua Liu Xing Bing Xue Za Zhi
December 2024
Division of Integration and Policy, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing102206, China.
To analyze the epidemic characteristics and trends of newly reported HIV-infected people among Chinese and Burmese in Dehong Dai and Jingpo Autonomous Prefecture (Dehong Prefecture) of Yunnan Province, China, from 2000 to 2023, and provide evidence for formµlating AIDS prevention and control measures for the Burmese living in Dehong. The data were obtained from the Chinese Disease Control and Prevention Information System. The distribution of HIV-infected people with different population characteristics was analyzed, and the Joinpoint regression model was used to analyze the temporal trend of crude detection rate in different genders, ethnicities, and ages.
View Article and Find Full Text PDFHigh Risk of HPV Related Preneoplastic and Neoplastic Vulvar Lesions in Women Living With HIV.
J Low Genit Tract Dis
December 2024
Neurosurgical Intensive Care Unit, Department of Neuroscience, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy.
Objective: We aimed to investigate the epidemiology of human papilloma virus (HPV)-related preneoplastic and neoplastic vulvar lesions in a large cohort of women living with HIV (WLWH).
Materials And Methods: We retrospectively selected 1,796 WLWH who had a gynecological examination, cervical cytology, high-risk (HR-) HPV test, vulvoscopy, and colposcopy with targeted biopsies when necessary between 1987 and 2020 at 2 Italian institutions. Univariable and multivariable regression analyses were carried out to test the association of the anamnestic and clinical data with the development of precancerous and cancerous lesions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!