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Malassezia species are lipophilic yeasts recognized for causing skin manifestations, such as pityriasis versicolor. In addition, Malassezia can lead to invasive infection, mostly intravascular catheter-associated sepsis-related lipid-containing total parenteral nutrition in neonates and immunocompromised hosts. We experienced a case of invasive pulmonary Malassezia infection in a patient with refractory ulcerative colitis undergoing immunosuppressive treatment without lipid-containing total parenteral nutrition.

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Malassezia-associated skin diseases in the pediatric population.

Pediatr Dermatol

September 2024

Section of Dermatology, Department of Medicine and Pediatrics, University of Chicago, Chicago, Illinois, USA.

Article Synopsis
  • Malassezia are yeast species that naturally live on healthy skin but can contribute to various skin disorders, especially in kids.
  • This review covers several skin conditions linked to Malassezia in infants, children, and adolescents, like pityriasis versicolor and seborrheic dermatitis.
  • The authors analyze existing research to provide insights on these conditions, including their symptoms, diagnosis, risk factors, treatment options, and theories on how Malassezia contributes to their development.
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Tinea versicolor (TV) is a fungal skin infection that classically affects adolescents and young adults. Occasionally, it may be seen on the face of infants. We report an unusual case of widespread cutaneous TV in a premature infant.

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Article Synopsis
  • The study investigates the virulence factors of Malassezia furfur, focusing on its role in bloodstream infections (BSI) and its activity in pityriasis versicolor (PV).
  • M. furfur strains from BSI patients exhibited higher biofilm production compared to those from PV patients, but displayed lower enzymatic activities like phospholipase, lipase, and hemolysin.
  • Antifungal susceptibility testing revealed that drugs like itraconazole and posaconazole were most effective against M. furfur, with minimum inhibitory concentrations indicating a stronger resistance profile in strains from BSI patients compared to those from PV patients.
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Background And Objective: Pityriasis rosea (PR), a common skin disease in young adults, may adversely affects the course of pregnancy and the unborn child.

Patients And Methods: Data from forty-six pregnant women with PR seen in the dermatological university clinic between 2003 and 2018 were analyzed and compared with patient data (n = 53) from previously published studies to determine the incidence and risk factors for an unfavorable pregnancy outcome after PR infection.

Results: Unfavorable pregnancy outcomes (defined as miscarriage, preterm delivery before week 37 of gestation, or birth weight < 2,500 g) were significantly less frequent in our study population than in a pooled cohort obtained from previously published studies (10.

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