Rotavirus vaccine virus shedding, viremia and clearance in infants with severe combined immune deficiency.

Pediatr Infect Dis J

From the *National Reference Centre for Enteric Viruses, University Hospital of Dijon, Dijon, France; †Paediatric Immunology, Haematology and Rheumatology Unit, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, and Faculté Paris Descartes, Paris, France; ‡Laboratory of Virology, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Published: March 2015

AI Article Synopsis

  • Two babies got a rotavirus infection even after getting the Rotarix vaccine.
  • The first baby had a serious health issue called severe combined immune deficiency, which means their immune system wasn't working well.
  • After receiving treatment through gene therapy, the first baby finally got better and the virus went away.

Article Abstract

We report for the first time Rotarix vaccine-acquired rotavirus infections with viremia in 2 infants vaccinated before being diagnosed with severe combined immune deficiency. Monitoring the first infant revealed that persistent rotavirus infection resolved after complete immune reconstitution was achieved by gene therapy.

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Source
http://dx.doi.org/10.1097/INF.0000000000000560DOI Listing

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