Chemoselective hydrogenation of carbonyl compounds and acceptorless dehydrogenative coupling of alcohols.

J Am Chem Soc

†Department of Chemistry and Biochemistry, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5, Canada.

Published: March 2015

OsHCl(CO)[κ(3)-PyCH2NHC2H4NHPtBu2] is the first efficient catalyst for chemoselective reduction of challenging unsaturated esters to enols and for acceptorless coupling of amines with MeOH and EtOH affording formamides and acetamides. The NMR, ESI-MS, and DFT data indicate a mechanism proceeding in the metal coordination sphere and producing no free organic intermediates.

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http://dx.doi.org/10.1021/ja512389yDOI Listing

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