It was revealed during examination of 91 patients with chronic nonspecific lung diseases for the blood titers of erythropoietin, erythrocytic chalones, erythrocyte hemolysis products and medium molecules that in the stage I respiratory failure, there were no material changes in the titres of erythrocyte hemolysis products, erythropoietin and medium molecules, whereas the titer of erythrocytic chalones appeared to be high. Stage III of the disease was also marked by no changes in the titer of erythrocyte hemolysis products. However, the titers of erythropoietin and medium molecules rose whereas the titer of erythrocytic chalones was reduced. In the stage II respiratory failure, the above enumerated factors of humoral regulation of erythropoiesis appeared similar to those in stage I. These data evidence that different compensatory reactions to hypoxia associated with chronic respiratory failure are implicated at the molecular, cellular and systemic levels. The up-to-date treatment and diagnostic process is not feasible, provided these reactions are not taken into consideration.
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It was revealed during examination of 91 patients with chronic nonspecific lung diseases for the blood titers of erythropoietin, erythrocytic chalones, erythrocyte hemolysis products and medium molecules that in the stage I respiratory failure, there were no material changes in the titres of erythrocyte hemolysis products, erythropoietin and medium molecules, whereas the titer of erythrocytic chalones appeared to be high. Stage III of the disease was also marked by no changes in the titer of erythrocyte hemolysis products. However, the titers of erythropoietin and medium molecules rose whereas the titer of erythrocytic chalones was reduced.
View Article and Find Full Text PDF[New knowledge of the structure and action of animal cell growth and hematopoiesis-regulating factors].
Z Gesamte Inn Med
October 1987
Wissenschaftsbereich Tierbiochemie, Sektion Tierproduktion und Veterinärmedizin, Karl-Marx-Universität Leipzig.
A survey is given of several new growth factors from tissues of animals, in particular of the endothelia cell growth factor (= heparin-binding growth factors), the multipotent growth factors from brain of cattle, the prostatropins as well as the growth factors for fibroblasts and glia-cells. Several more recent recognitions on the importance of the insulinlike growth factors, the tumour growth factors and the chalones are described. For the regulation of the haemotopoiesis the factor furthering the formation of multicolonies (= pluripoetin, interleukin 3), the factor furthering the formation of erythrocyte-macrophages colonies, the factor furthering the formation of macrophage-colonies and the erythropoietin are of importance.
View Article and Find Full Text PDFIt was demonstrated with the use of the immunological tests that in acute posthemorrhagic anemias, the blood chalone content was low whereas in anemias of the leukemic origin it was elevated. In secondary erythrocytis, the chalone titre rose to a greater degree than in polycythemia vera. The testing of chalone blood factors may play a role in differential diagnosis of some types of erythropoiesis abnormalities.
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