AI Article Synopsis
- Inflammatory processes may contribute to the progression of non-rheumatic aortic stenosis (AS), particularly in patients undergoing major surgery.
- Major non-cardiac surgery (MNCS) was linked to a significantly higher annual increase in peak pressure gradient across the aortic valve, indicating quicker progression of AS compared to non-MNCS patients.
- The study suggests that MNCS is an independent factor predicting rapid hemodynamic progression of non-rheumatic AS.
Article Abstract
Background: Inflammatory processes are suggested to play a pathogenic role in the development and progression of non-rheumatic aortic stenosis (AS). Major surgery causes an inflammatory reaction. With the increasing prevalence of non-rheumatic AS, the number of affected patients undergoing major surgery increases. We hypothesized that major non-cardiac surgery (MNCS) could accelerate the progression of non-rheumatic AS.
Methods And Results: We enrolled 218 consecutive patients with non-rheumatic AS who underwent transthoracic echocardiography (TTE) at least twice more than 6 months apart. Study patients were divided into the MNCS group and the non-MNCS group. The MNCS group consisted of patients who underwent MNCS during the TTE follow-up interval. At baseline, peak pressure gradient across the aortic valve (AVG) was similar between the groups. Also baseline clinical characteristics and TTE follow-up interval were similar. The annual rate of peak AVG increase was much higher in the MNCS group than in the non-MNCS group. The proportion of patients with rapid hemodynamic progression was much higher in the MNCS group than in the non-MNCS group. Multiple logistic regression analysis showed that MNCS was an independent predictor of rapid hemodynamic progression of non-rheumatic AS.
Conclusions: The present study indicates for the first time that MNCS is associated with the rapid progression of non-rheumatic AS.
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| http://dx.doi.org/10.1253/circj.CJ-14-1111 | DOI Listing |
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