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Phylodynamic Investigation of Yellow Fever Virus Sheds New Insight on Geographic Dispersal Across Africa.
Evol Bioinform Online
December 2024
Department of Biological Sciences, Covenant University, Ota, Nigeria.
Background: Molecular epidemiology has shown the presence of four genotypes circulating across Africa, a paucity of data exists regarding phylogeography of the African Yellow fever (YF) genotypes. The need to fill this gap with spatiotemporal data from continuous YF outbreaks in Africa conceptualized this study; which aims to investigate the most recent transmission events and directional spread of yellow fever virus (YFV) using updated genomic sequence data.
Methods: Yellow fever sequence data was utilized along with epidemiologic data from outbreaks in Africa, to analyze the case/fatality distribution and genetic diversity.
Characterization of Laboratory-Confirmed Creutzfeldt-Jakob Disease From 3 Ontario Tertiary Care Centers Between 2012 and 2022: A Retrospective Cohort Study.
Open Forum Infect Dis
October 2024
School of Nursing, York University, Toronto, Ontario, Canada.
Article Synopsis
- - The study analyzed data from 30 patients with laboratory-confirmed Creutzfeldt-Jakob disease (CJD) at three Ontario hospitals between 2012 and 2022, revealing specific epidemiology trends and diagnostic timelines in this region.
- - Patients exhibited key symptoms like loss of coordination and memory loss, with an average delay of 91 days from symptom onset to testing, and MRI and EEG results supported the diagnosis in most cases.
- - After diagnosis, a significant number of patients faced poor outcomes, with an average of 121 days from symptom onset to death, emphasizing the need for quicker identification and testing of CJD symptoms.
Hearing Loss in Children with 22q11.2 Deletion Syndrome.
Laryngoscope
September 2024
22q and You Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, U.S.A.
Objectives: Hearing loss is considered common in children with 22q11.2 deletion syndrome (22q11.2DS), with a few prior studies reporting a 32%-78% prevalence; mild-moderate conductive hearing loss has been reported most commonly.
View Article and Find Full Text PDFOutcome of hospitalized patients with COVID-19 and predictors at the Buea Regional Hospital, South West region of Cameroon.
Pan Afr Med J
July 2024
Faculty of Health Sciences, University of Buea, Buea, Cameroon.
Introduction: there is a paucity of data on the epidemiology of COVID-19 infection in Cameroon with a few studies limited to big urban cities. The objective of this study was to describe the clinical characteristics and outcomes of hospitalized patients with COVID-19 at the Buea Regional Hospital, in the South West region of Cameroon.
Methods: this was a retrospective cross-sectional study.
The comparison of COVID-19 vs seasonal influenza in children.
Pediatr Int
December 2023
Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Background: Influenza in children has been well described, whereas there has been a paucity of pediatric data regarding COVID-19. It is crucial for clinicians to differentiate cases of COVID-19 from cases of influenza because of the upcoming influenza season in the new pandemic era.
Methods: This retrospective study included pediatric patients who were diagnosed with laboratory-confirmed COVID-19 between March and September 2020, or seasonal influenza between October 2019 and March 2020.
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