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From Viral Infection to Skin Affliction: Unveiling Mechanisms of Cutaneous Manifestations in COVID-19 and Post-COVID Conditions.
J Invest Dermatol
February 2025
Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada; Division of Dermatology, Women's College Hospital, Toronto, Canada. Electronic address:
COVID-19 skin manifestations are multifaceted, ranging from urticaria, morbilliform or papulovesicular rash, livedoid purpuric lesions, and to pseudochilblains (also called COVID toes). Recent insights into the mechanism of these manifestations have highlighted that morbilliform, papulovesicular, and livedoid/purpuric rashes are related to virus-induced endothelial cell damage and linked to moderate-to-severe disease, whereas pseudochilblains are related to an exaggerated IFN-1 production by plasmacytoid dendritic cells in protected individuals. In this paper, we will review the clinical and physiopathological features of cutaneous COVID-19 manifestations in relation to the direct viral cytopathic effects and dysregulated IFN-1 responses.
View Article and Find Full Text PDFHuman Metapneumovirus Associated With Acute Hemorrhagic Oedema of Infancy: A Case Report.
Cureus
November 2024
Paediatrics, NMC Specialty Hospital, Dubai, ARE.
Acute Haemorrhagic Oedema of Infancy (AHOI), also known as Acute Hemorrhagic Edema of Infancy (AHEI), is characterized by purpuric skin lesions, edema, and fever. It is classified as a form of cutaneous leukocytoclastic vasculitis. Clinically, AHOI presents with targetoid, purplish spots on the face and limbs, accompanied by the sudden onset of peripheral edema.
View Article and Find Full Text PDFFat embolism syndrome following femoral shaft fracture: A case report and diagnostic considerations.
Radiol Case Rep
February 2025
Faculty of Medicine, Mazandaran University of Medical Sciences, Mazandaran, Iran.
Fat embolism syndrome (FES) is a rare but serious complication that can arise after long bone fractures or orthopedic surgeries. This case report presents a 40-year-old male who developed FES following surgical fixation of a femoral shaft fracture using 2 plates. The day after surgery, the patient exhibited tachycardia, respiratory distress, and a fever of 38.
View Article and Find Full Text PDFPurpuric paradigm: Multiple purpuric lesions on palms.
Indian J Dermatol Venereol Leprol
November 2024
Department of Dermatology, Venereology and Leprology, PGIMER, Chandigarh, India.
Urticarial vasculitis.
Curr Opin Rheumatol
January 2025
Marmara University School of Medicine, Department of Dermatology, Istanbul, Türkiye.
Article Synopsis
- Urticarial vasculitis (UV) is a rare condition that can range from mild skin issues to serious systemic problems, and recent research focuses on its causes, diagnosis, and treatment options.
- New triggers for UV associated with SARS-CoV-2 and COVID-19 vaccines have been noted, along with a new clinical-dermoscopic method for diagnosis that reduces reliance on skin biopsies.
- Treatments such as antihistamines, corticosteroids, and rituximab show promise for success and long-lasting remission, while epidemiological studies show good survival rates but highlight certain severe health issues that can increase mortality.
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