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Chronic lymphocytic leukemia/small lymphocytic lymphoma, version 1.2015. | LitMetric

AI Article Synopsis

  • * New monoclonal antibodies (ofatumumab and obinutuzumab) have led to effective chemoimmunotherapy options.
  • * Recently approved small molecule kinase inhibitors (ibrutinib and idelalisib) are beneficial for elderly patients and those with poor prognoses who can't tolerate standard treatments. *

Article Abstract

Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are different manifestations of the same disease, which are managed in the same way. The advent of novel monoclonal antibodies (ofatumumab and obinutuzumab) led to the development of effective chemoimmunotherapy regimens. The recently approved small molecule kinase inhibitors (ibrutinib and idelalisib) are effective treatment options for CLL in elderly patients with decreased tolerance for aggressive regimens and in patients with poor prognostic features who do not benefit from conventional chemoimmunotherapy regimens. This portion of the NCCN Guidelines for Non-Hodgkin's Lymphomas describes the recent specific to the incorporation of recently approved targeted therapies for the management of patients with newly diagnosed and relapsed or refractory CLL/SLL.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841457PMC
http://dx.doi.org/10.6004/jnccn.2015.0045DOI Listing

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