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Nicorandil and cutaneous ulcerations, their misdiagnosis and consequences: Illustration by five cases reports and a review of the French pharmacovigilance database.
Therapie
October 2018
Inserm, centre régional de pharmacovigilance du Nord-Pas-de-Calais, U1171, université de Lille 2, CHU de Lille, 1, place de Verdun, 59037 Lille cedex, France.
While physicians increasingly recognize nicorandil-related mucocutaneous ulcerations, there are still misdiagnoses, particularly in the case of unusual location and late onset ulceration after nicorandil introduction. The goal of our study was to remind clinicians about the link between nicorandil use and the development of cutaneous ulcerations and to highlight the risk of misdiagnosis. We describe five reports diagnosed by the same dermatologist, complemented by an analysis of the French pharmacovigilance database (FPVD) from 1 January 1994 to 5 January 2017.
View Article and Find Full Text PDFHypertrophic obstructive cardiomyopathy with multiple coronary arteries to right ventricular microfistulas: a case report and review of the literature.
J Med Case Rep
January 2017
Department of Cardiology, Swai Man Singh Medical College, Jaipur, Rajasthan, India.
Background: Coronary artery microfistulas are a rare anomaly; their association with hypertrophic cardiomyopathy is even rarer and can lead to serious cardiac complications owing to coronary steal phenomena such as angina pectoris, myocardial infarction, congestive heart failure, ventricular and supraventricular arrhythmias, syncope, and sudden death.
Case Presentation: A 32-year-old Indian woman presented to our institute with severe angina on exertion and multiple episodes of pre-syncope. Echocardiography revealed hypertrophic obstructive cardiomyopathy.
Penile Ulceration Secondary to Nicorandil Use.
Urol Case Rep
January 2017
Department of General Surgery, Daisy Hill Hospital, Newry BT35 8DR, UK.
Nicorandil is a medication used for treatment and prevention of angina pectoris. Its mode of action involves both arterial and venous vasodilation. Although there are numerous known side effects, one of the more unusual, adverse reactions is ulceration of the external genitalia.
View Article and Find Full Text PDFThe platysma myocutaneous flap is rarely reported as an option for reconstruction in the head and neck. In our experience it is a reliable flap that is easy to raise, has a limited risk of morbidity at the donor site, and allows for early recommencement of oral function. We report a patient with an unusually aggressive orocutaneous fistula that complicated the simple extraction of teeth.
View Article and Find Full Text PDFNicorandil, an unusual ulcer etiology.
Int J Colorectal Dis
November 2015
Serviço de Cirurgia, Centro Hospitalar Lisboa Norte - Hospital de Santa Maria, EPE, Avenida Professor Egas Moniz, 1649-035, Lisbon, Portugal.
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