Understanding the processes that drive the formation of synapses between specific neurons within a circuit is critical to understanding how neural networks develop. A new study of synapse formation between motor neurons and pre-synaptic partners highlights the importance of dendrite placement.
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Article Synopsis
- - RANKL is identified as a key player in periodontitis, primarily influencing osteoclast differentiation and acting as a link between bone and the immune system, showcasing a complex role beyond its initial recognition as an activator of dendritic cells (DCs).
- - In studies using ligature-induced periodontitis (LIP), rapid bone loss was observed, which eventually stopped despite the presence of the ligature, indicating a connection to immunosuppressive conditions in the gingiva associated with T regulatory (Treg) cell expansion.
- - Experiments with K14-RANKL mice, which overexpress RANKL in gingival cells, revealed that increased RANKL leads to a favorable balance of immune cells
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