For some years, policy makers and medical scientists have both begun to focus more on chronic noncommunicable diseases. It is well known that cardio-cerebrovascular disease, tumors, diabetes, and chronic obstructive pulmonary disease (COPD), are considered areas of major interest in many scientific projects and health programs. The economic impact of cardio-cerebrovascular disease in EU alone is more than EUR 200 billion, while tumors have an impact of EUR 150 billion. The direct and indirect cost of brain disorders exceeds EUR 700 billion a year. Among the brain disorders, the devastating impact of dementia on affected individuals and the burden imposed on their families and society has made prevention and treatment of dementia a public health priority. Interventions that could merely delay the onset of dementia by 1 year would result in a more than 10% decrease in the global prevalence of dementia in 2050. Unfortunately, there are no known interventions that currently have such effectiveness. The manifestations of age-related hearing loss in many older adults are subtle and, thus, hearing loss is often perceived as an unfortunate but inconsequential part of aging. Researchers report that hearing loss seems to speed up age-related cognitive decline. Researchers suggest that treating hearing loss more aggressively could help delay cognitive decline and dementia. Furthermore, there is an increasing interest in better understanding the pathophysiologic correlations between hearing loss and dementia. Hearing loss in older adults, in fact, is associated independently with poorer cognitive functioning, incident dementia, and falls. Further research investigating the basis of this connection as well as the pathomechanism of the two diseases will further our ability to treat dementia.
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http://dx.doi.org/10.1159/000371595 | DOI Listing |
J Voice
January 2025
Department of Speech Therapy, Physiotherapy and Occupational Therapy, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, São Paulo, São Paulo, Brazil. Electronic address:
Purpose: This study aimed to compare the self-perception of voice at different times and the influence of age, number of infections, underlying diseases, and occupational voice use among individuals with Coronavirus Disease 2019 (COVID-19), with or without a history of hospitalization.
Methods: Data were collected from adults and older adults with COVID-19, treated at a Brazilian Military Hospital between April 2020 and May 2023. The questionnaire was sent by email and a messaging application.
Health Promot Pract
January 2025
Colorado School of Public Health, Aurora, CO, USA.
In this commentary, we, a recent Master of Public Health (MPH) graduate with hearing loss and a course instructor, share what we learned about classroom accessibility while participating in a semester-long qualitative research methods course offered during the COVID-19 pandemic. We complement our reflections on working together with findings from a student field project focused on the lived classroom experiences of graduate students with hearing loss. The field project revealed that students adapted to increased communication challenges in their learning environments without requesting official accommodations due to stigma and a desire to limit their burden on others.
View Article and Find Full Text PDFExp Eye Res
January 2025
Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, 518040 Guangdong, China. Electronic address:
Usher syndrome is a rare autosomal recessive genetic disorder that primarily affects both vision and hearing, manifesting as sensorineural hearing loss and progressive vision loss caused by retinitis pigmentosa. The pathogenesis of retinal degeneration in Usher syndrome is still largely unknown. In this study, a novel Ush2a knockout mouse model was successfully constructed using CRISPR/Cas9 technology.
View Article and Find Full Text PDFHair cells (HCs) are essential for vestibular function, and irreversible damage to vestibular HCs in mammals is closely associated with vertigo. The stimulation of HC regeneration through exogenous gene delivery represents an ideal therapeutic approach for restoring vestibular function. Overexpression of Atoh1, Pou4f3, and Gfi1 (collectively referred to as APG) has demonstrated efficacy in promoting HC regeneration in the cochlea.
View Article and Find Full Text PDFScience
January 2025
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Cochlear inner hair cells (IHCs) and outer hair cells (OHCs) require different transcription factors for their cell fate stabilization and survival, suggesting separate mechanisms are involved. Here, we found that the transcription factor Casz1 was crucial for early IHC fate consolidation and for OHC survival during mouse development. Loss of Casz1 resulted in transdifferentiation of IHCs into OHCs, without affecting OHC production.
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