AI Article Synopsis
- Overnutrition can lead to obesity, which negatively impacts fertility by causing anovulation and affecting oocytes and embryos during the sensitive periconceptional period (from folliculogenesis to implantation).
- Studies show that oocytes from obese females may have smaller sizes and mitochondrial issues, likely due to changes in ovarian fluid composition.
- Obesity also alters the microenvironment in reproductive organs, leading to preimplantation embryos with fewer cells and increased proinflammatory gene expression, but more research is needed to fully understand these effects.
Article Abstract
Overnutrition may lead to obesity. Maternal obesity may affect fertility not only via anovulation, but also through direct effects on oocytes and preimplantation embryos, indicating that the periconceptional period is sensitive to conditions of overnutrition. The periconceptional period includes from folliculogenesis to implantation. Animal model studies suggest that oocytes derived from obese females usually have a small size and mitochondrial abnormalities. These disruptions are probably induced by changes in the components of the ovarian follicular fluid. Experimental evidence also suggests that obesity may affect the microenvironment in oviducts and uterus, resulting in development of preimplantation embryos with reduced cell numbers and up-regulation of proinflammatory genes. However, further research is needed for in-depth characterization of the effects of maternal obesity during the periconceptional period.
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| http://dx.doi.org/10.1016/j.endonu.2015.01.004 | DOI Listing |
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