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A RETREG1 variant is associated with hereditary sensory and autonomic neuropathy with acral self-mutilation in purebred German Spitz.
Anim Genet
December 2024
Institut de Génétique et Développement de Rennes (IGDR) - UMR6290, CNRS, Université de Rennes, Rennes, France.
Article Synopsis
- Hereditary sensory and autonomic neuropathies (HSAN) are genetic disorders affecting the peripheral nervous system, with at least 16 known genetic loci in humans, while similar conditions like acral mutilation syndrome (AMS) have been noted in dogs, especially impacting their quality of life.
- A study focused on a purebred German Spitz showed early-onset HSAN/AMS, leading to severe self-mutilation due to loss of pain sensation, and whole-genome sequencing identified a variant in the RETREG1 gene as the likely cause.
- This variant impairs neuron function and confirms its role in the recessive form of HSAN/AMS for the breed, highlighting
Fractional CO2 Laser Versus Microneedling Combined with Narrowband Ultraviolet and Topical Steroid for Treating Non-Segmental Vitiligo in Treatment-Resistant Localizations: A Comparative Randomized Clinical Trial Study.
J Lasers Med Sci
August 2024
Skin and Stem Cell Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Vitiligo poses a significant challenge, particularly in treatment-resistant areas such as acral regions. This study aimed to evaluate the effectiveness and safety of combining fractional CO2 laser and microneedling with conventional therapies for non-segmental vitiligo in resistant areas. A randomized clinical trial with a paired design was conducted on 84 individuals with non-segmental vitiligo and treatment-resistant lesions.
View Article and Find Full Text PDFTemperature-responsive hydrogel-grafted vessel-on-a-chip: Exploring cold-induced endothelial injury.
Biotechnol Bioeng
October 2024
Key Laboratory of Smart Biomaterials of Zhejiang Province, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China.
Article Synopsis
- * Researchers developed a new microfluidic bioreactor called "vessel-on-a-chip" that uses a thermosensitive hydrogel to mimic blood flow changes under cold stress effectively.
- * This novel technology can replicate cold-induced endothelial injuries, showing potential for advancing research on cold-related cardiovascular diseases and drug testing.
Limb Ischemic Necrosis Secondary to Microvascular Thrombosis: A Brief Historical Review.
Semin Thromb Hemost
July 2024
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Ischemic limb injury can be broadly classified into arterial (absent pulses) and venous/microvascular (detectable pulses); the latter can be divided into two overlapping disorders-venous limb gangrene (VLG) and symmetrical peripheral gangrene (SPG). Both VLG and SPG feature predominant acral (distal) extremity ischemic necrosis, although in some instances, concomitant nonacral ischemia/skin necrosis occurs. Historically, for coagulopathic disorders with prominent nonacral ischemic necrosis, clinician-scientists implicated depletion of natural anticoagulants, especially involving the protein C (PC) system.
View Article and Find Full Text PDFExploring the Efficacy of Fractional Carbon Dioxide Laser as an Add-on Combination to Conventional Therapies for Treatment-Resistant Vitiligo (A Review Article).
J Lasers Med Sci
November 2023
Mental Health Research Center, Social Injury Prevention Research Institute, Iran University of Medical Sciences, Tehran, Iran.
Vitiligo, a dermatological disorder that leads to depigmented skin patches, presents a significant challenge, particularly in resistant areas such as acral regions. Fractional CO2 laser therapy holds promise as an adjunct to conventional treatment, enhancing repigmentation. This review comprehensively explores its efficacy and safety in resistant-to-treatment vitiligo.
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