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Very Late-Onset Neurodegeneration with Brain Iron Accumulation Associated with Mild Chorea: A Clinicopathological Case.
Mov Disord Clin Pract
March 2025
Unit of Pathology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Background: Neurodegeneration with Brain Iron Accumulation (NBIA) rarely manifests after the age of 50 years. The phenotype in these cases is most often parkinsonism.
Objectives: To present the case with the oldest age of NBIA onset reported so far.
Central Pathologies Imitating Peripheral Causes of Vertigo.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of ENT & HNS, Command Hospital (EC), Kolkata, India.
To differentiate central vertigo mimicking peripheral vestibular diseases with proper history taking, examination and imaging to enable early diagnosis and management. This was an Observational Study carried out over two years and targeted patients across all age groups presenting with complaints of vertigo in ENT OPD of hospitals of the Armed Forces. All patients in all age groups for both genders were included, even those who had presented with recurring symptoms having been managed conservatively elsewhere.
View Article and Find Full Text PDFThe lateralized LC-NAergic system distinguishes vicarious versus direct fear in mice.
Nat Commun
March 2025
Center for Cognition and Sociality, Institute for Basic Science (IBS), 55 Expo-ro, Yusung-gu, Daejeon, 34126, Republic of Korea.
Fear can be induced either directly through self-experience of aversive events or vicariously by observing conspecifics experiencing such events. The locus coeruleus-norepinephrine (LC-NA) system is crucial in fear responses and cognitive processes. We investigated whether the LC-NA system differentially processes these two types of fear, direct and vicarious in male mice.
View Article and Find Full Text PDFPost-contrast Susceptibility Weighted Imaging in Multiple Sclerosis MRI Improves the Detection of Enhancing Lesions.
Clin Neuroradiol
March 2025
Radiology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Carrer de Feixa Llarga SN, 08907, Barcelona, Spain.
Objectives: MRI is essential for monitoring multiple sclerosis (MS). Contrast-enhanced T1-weighted imaging (T1WI+C) detects active inflammatory lesions indicating blood-brain barrier breakdown and is relevant for disease monitoring and treatment optimization. Susceptibility-weighted imaging (SWI) may be included in the imaging protocol for detecting MS-specific features, such as the presence of central veins or paramagnetic rim lesions.
View Article and Find Full Text PDFPontine and Extrapontine Myelinolysis: Risk Factors and Characterization of Patients Diagnosed in Three Decades in a Tertiary Center.
Rev Invest Clin
March 2025
Departments of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Background: Osmotic demyelination syndrome is a rare neurological disorder caused by damage to the myelin sheath of oligodendrocytes, typically due to a rapid increase in serum osmolarity. Objective: The objective of the study was to investigate the factors associated with the development of pontine or extrapontine myelinolysis. Methods: A retrospective, observational study which included patients with magnetic resonance imaging-confirmed diagnosis of pontine and extrapontine myelinolysis from 1990 to 2024 at a referral hospital in Mexico City.
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