The paper studies the effect of a blocking agent, calcium-niphedipine (corinfar), single or associated with other hypertensors (diuretic, sympathico-colitic), in a dose of 30 mm (3 X 10 mg) administered for about 8-10 days on a lot of 90 patients, men and women, with essentially noncomplicated AHT or associated with: pyelonephritis, cardiac insufficiency, ischemic cerebral stroke, rhythm and conduction disturbances. The systolic AT values of the patients ranged between 160 and 300 mmHg and the diastolic AT between 90 and 150 mmHg. The systolic AT decreased significantly with 40-117 mmHg and the diastolic AT with 15-55 mmHg. The drug was well tolerated and no side effect was noticed. In two cases, the AT values were not influenced by the treatment.
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Adv Ther
December 2024
Global Medical and Patient Affairs, Servier, Suresnes, France.
Introduction: The aim of the observational SIMPLE study was to assess real-life effectiveness and safety of a single-pill combination (SPC) of perindopril arginine/amlodipine in a broad range of subjects with newly diagnosed mild-to-moderate hypertension treated in Canadian general practice.
Methods: Treatment-naïve participants aged 18-65 years with mild-to-moderate hypertension, whose physicians decided to initiate the perindopril/amlodipine SPC, were recruited from Canadian clinical practice from October 2017 to February 2019. Participants were followed at 3- (M3) and 6-month (M6) visits after treatment initiation.
Adv Sci (Weinh)
December 2024
Graduate School of Biomedical Engineering, Faculty of Engineering, and Tyree Institute of Health Engineering (IHealthE), UNSW Sydney, Kensington Campus, Sydney, NSW, 2052, Australia.
Hemodynamic stabilization is crucial in managing acute cardiac events, where compromised blood flow can lead to severe complications and increased mortality. Conditions like decompensated heart failure (HF) and cardiogenic shock require rapid and effective hemodynamic support. Current mechanical assistive devices, such as intra-aortic balloon pumps (IABP) and extracorporeal membrane oxygenation (ECMO), offer temporary stabilization but are limited to short-term use due to risks associated with prolonged blood contact.
View Article and Find Full Text PDFSci Rep
December 2024
Medical College, Wuhan University of Science and Technology, Wuhan, China.
Aspirin may be necessary for some patients with cardiovascular disease, but previous studies on the use and dosage of aspirin and the association with hypertension have been inadequate. The results of existing studies have been somewhat inconsistent. Our study was designed to assess the association between prophylactic aspirin use and hypertension in U.
View Article and Find Full Text PDFComput Biol Med
December 2024
Faculty of Chemical & Petroleum Engineering, University of Tabriz, Tabriz, Iran. Electronic address:
Background And Objectives: The liver, a vital metabolic organ, is always susceptible to various diseases that ultimately lead to fibrosis, cirrhosis, acute liver failure, chronic liver failure, and even cancer. Optimal and specific medicine delivery in various diseases, hepatectomy, shunt placement, and other surgical interventions to reduce liver damage, transplantation, optimal preservation, and revival of the donated organ all rely on a complete understanding of perfusion and mass transfer in the liver. This study aims to simulate the computational fluid dynamics of perfusion and the temporal-spatial distribution of a medicine in a healthy liver to evaluate the hemodynamic characteristics of flow and medicine transport with the purpose of more effective liver treatment.
View Article and Find Full Text PDFNeurol Int
December 2024
Division of Rehabilitation Medicine, Department of Medicine, National University Hospital, Singapore 119228, Singapore.
Background/objectives: Orthostatic hypotension (OH) is highly prevalent in hospitalized patients and can lead to major consequences. The prevalence of OH among patients with stroke has also been reported to be high in in-patient cohorts. However, no previous analysis has focused exclusively on patients with hemorrhagic stroke, a group that may have a different disease profile, including a greater need for blood pressure control and surgical intervention.
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