The spectral, fluorescent and functional properties of ferric oxide and ferric hydroxide nanoparticles loaded with doxorubicin and stabilized with citric acid or lysine were studied in comparison with free doxorubicin. Their effect on the opening of calcium-induced mitochondrial pore and the possibility of the controlled release of doxorubicin under the influence of redox stimuli were investigated. The data show that the effect of nanoparticles on mitochondria depends on the type of a stabilizer. The spectral and fluorescence methods used allow us to estimate the presence or absence of free doxorubicin in solution of nanoparticles and the:concentration of bound doxorubicin. It is shown that the dithiotreitol and glutathione increase the amplitude of absorption and fluorescence of doxorubicin during incubation with nanoparticles. It is assumed that this effect may be associated with the reduction of the oxidized iron by thiols with subsequent release of doxorubicin.
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Food Chem
January 2025
School of Food Science and Engineering, Hainan University, Haikou 570228, China.
Due to the fact that association colloids were formed in krill oil, the oxidation mechanism of krill oil was more complicated. In this study, water-soluble ferrous sulfate (Fe(SO)), oil-soluble ferrous fumarate (CHFeO) and insoluble ferric oxide (FeO) were added to krill oil and stored at 60 °C for accelerated oxidation. Peroxide value, thiobarbituric acid reactive substances and aldehyde content showed that Fe(SO) had a stronger pro-oxidative effect.
View Article and Find Full Text PDFCurr Cancer Drug Targets
January 2025
Department of Clinical Laboratory, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, China.
Background: Lenvatinib is an oral tyrosine kinase inhibitor that selectively inhib-its receptors involved in tumor angiogenesis and tumor growth. It is an emerging first-line treatment agent for hepatocellular carcinoma (HCC). However, there is no intravenous ad-ministration of Lenvatinib.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Faculty of Science, University of the Fraser Valley, Abbotsford, BC V2S 7M8, Canada.
This study presents a novel FeO/C composite material synthesized from red mud through a process of magnetic roasting and separation. The research explores the impact of FeO/C dosages, sodium persulfate (PS) concentrations, and initial solution pH on the chemical oxygen demand (COD) removal efficiency using Acid Orange 7 as a model pollutant. Optimal conditions were identified as 3 g/L FeO/C, 20 mM PS, and an initial pH of 2, achieving a 94.
View Article and Find Full Text PDFJ Hazard Mater
January 2025
MOE Key Laboratory of Surficial Geochemistry, School of Earth Sciences and Engineering, Nanjing University, Nanjing, Jiangsu 210023, China. Electronic address:
Agricultural soils in karst regions present a remarkable paradox where high geochemical background levels of heavy metals correspond with unexpectedly low crop uptake, challenging traditional risk assessment frameworks and limiting agricultural development. To decode this paradox, we investigated the geochemical speciation of cadmium (Cd), nickel (Ni), and zinc (Zn) in soil-rice systems in southwestern China, which collectively constitute the world's largest continuous karst region and represent diverse soil weathering stages. We employed three chemical extraction methods that revealed reactive pools ranking as Cd (58.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
January 2025
National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt.
Iron oxide nanoparticles, recognized for their superparamagnetic properties, are promising for future healthcare therapies. However, their extensive use in medicine and electronics contributes to their discharge into our environments, highlighting the need for further research on their cellular damage effects on aquatic organisms. While the detrimental properties of other compounds have been stated in the early-life stages of fish, the cytotoxic consequences of superparamagnetic iron oxide nanoparticles (SPIONs) in these stages are still unexplored.
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