Futurescapes: evidence expectations in the USA for comparative effectiveness research for drugs in 2020.

J Comp Eff Res

Office of Health Economics; 7th Floor, Southside, 105 Victoria Street, London, SW1E 6QT, UK.

Published: August 2015

Aim: Explore key factors influencing future expectations for the production of evidence from comparative effectiveness research for drugs in the USA in 2020 and construct three plausible future scenarios.

Materials & Methods: Semistructured key informant interviews and three rounds of modified Delphi with systematic scenario-building methods.

Results & Conclusion: Most influential key factors were: health delivery system integration; electronic health record development; exploitation of very large databases and mixed data sources; and proactive patient engagement in research. The scenario deemed most likely entailed uneven development of large integrated health systems with pockets of increased provider risk for patient care, enhanced data collection systems, changing incentives to do comparative effectiveness research and new opportunities for evidence generation partnerships.

Download full-text PDF

Source
http://dx.doi.org/10.2217/cer.15.6DOI Listing

Publication Analysis

Top Keywords

comparative effectiveness
12
effectiveness drugs
8
key factors
8
futurescapes evidence
4
evidence expectations
4
expectations usa
4
usa comparative
4
drugs 2020
4
2020 aim
4
aim explore
4

Similar Publications

Mesoporous silica exhibits a diverse range of applications owing to its pore structure and inter-pore correlation. Consequently, quantitative characterization of its mesoscopic structure is extremely crucial to reciprocate its potential applications. In this work, we utilized the chemical and aerosol routes to successfully synthesize granular, porous silica with an average pore size in the range of ∼5-10 nm and different degrees of structural correlation among its pores.

View Article and Find Full Text PDF

This study reports on the development of a highly sensitive non-enzymatic electrochemical sensor based on a two-dimensional TiCT/MWCNT-OH nanocomposite for the detection of paraoxon-based pesticide. The synergistic effect between the TiCT nanosheet and the functionalized multi-walled carbon nanotubes enhanced the sensor's conductivity and catalytic activity. The nanocomposite demonstrates superior electrochemical and electroanalytical performance compared to the pristine TiCT and MWCNT-OH in detecting paraoxon-ethyl in fruit samples (green and red grapes), with a linear response range from 0.

View Article and Find Full Text PDF

Safety and immunogenicity of an mRNA-1273 vaccine booster in adolescents.

Hum Vaccin Immunother

December 2025

Research and Development, Infectious Disease, Moderna, Inc., Cambridge, MA, USA.

Safety, immunogenicity, and effectiveness of an mRNA-1273 50-μg booster were evaluated in adolescents (12-17 years), with and without pre-booster SARS-CoV-2 infection. Participants who had received the 2-dose mRNA-1273 100-µg primary series in the TeenCOVE trial (NCT04649151) were offered the mRNA-1273 50-μg booster. Primary objectives included safety and inference of effectiveness by establishing noninferiority of neutralizing antibody (nAb) responses after the booster compared with the nAb post-primary series of mRNA-1273 among young adults in COVE (NCT04470427).

View Article and Find Full Text PDF

Background: Kentucky is within the top five leading states for breast mortality nationwide. This study investigates the association between neighborhood socioeconomic disadvantage and breast cancer outcomes, including surgical treatment, radiation therapy, chemotherapy, and survival, and how associations vary by race and ethnicity in Kentucky.

Methods: We conducted a retrospective cohort analysis using data from the Kentucky Cancer Registry (KCR) for breast cancer patients diagnosed between 2010 and 2017, with follow-up through December 31, 2022.

View Article and Find Full Text PDF

Background: Elbow injuries are prevalent among professional baseball pitchers as nearly 25% undergo ulnar collateral ligament reconstruction. Pitch type, ball velocity, and spin rate have been previously hypothesized to influence elbow varus torque and subsequent risk of injury, but existing research is inconclusive.

Purpose: To examine elbow varus torque, cumulative torque, and loading rate within professional pitchers throwing fastball, curveball, change-up, and slider pitches, as well as to identify potential influences of ball spin on the elbow.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!