AI Article Synopsis
- Critical limb ischemia (CLI) is a severe form of peripheral arterial disease that leads to issues like rest pain, ulcers, or gangrene, with a high 1-year mortality and amputation rate of 25%.
- Historically, the main treatment was bypass surgery using the patient’s veins, but new endovascular techniques and innovations are changing how CLI is treated.
- A comprehensive management plan for CLI patients includes advanced medical care, wound treatment, and timely revascularization, highlighting the latest endovascular options like balloon angioplasty and emerging technologies such as drug-eluting stents.
Article Abstract
Critical limb ischemia (CLI) represents an advanced disease state of peripheral arterial disease. It manifests as lower extremity ischemic rest pain or ischemic skin lesions leading to ulceration or gangrene. Patients with CLI often have multiple medical comorbidities and a 1-year mortality rate of 25% and a 1-year amputation rate of 25%. Historically, bypass surgery with autogenous veins for flow restoration has been the first-line therapy for CLI. However, advances in endovascular techniques and device technology have changed the treatment paradigm. Catheter-based technologies are rapidly evolving at a rate that is outpacing large-scale studies evaluating relevant clinical outcomes. Patients with CLI require a multidisciplinary management approach centered on aggressive medical therapies, wound care and prompt revascularization, with an emphasis on limb salvage. This review summarizes the contemporary endovascular therapies including balloon angioplasty, atherectomy and bare-metal stenting. In addition, we review emerging technologies, such as drug-eluting stents, drug-coated balloons and chronic total occlusion recanalization devices.
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| http://dx.doi.org/10.1586/14779072.2015.1019472 | DOI Listing |
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