NIR-triggered drug delivery by collagen-mediated second harmonic generation.

Adv Healthc Mater

Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

Published: June 2015

Second harmonic generation is a process through which nonlinear materials such as collagen can absorb two photons and scatter one with twice the energy. Collagen upconverts 730 nm (near-IR) to 365 nm (UV) through second harmonic generation, which cleaves a molecule bound to collagen via a UV-sensitive linker.

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Source
http://dx.doi.org/10.1002/adhm.201400768DOI Listing

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