Objective: To study the microwave processing method of Achyranthis Bidentatae Radix processed with wine.

Methods: The content of total saponins, oleanolic acid and β-ecdysterone were determined as the indices to get the optimal microwave processing technology by orthogonal design.

Results: The best technology of Achyranthis Bidentatae Radix processed with wine were:the amount of vinegar was 20%, moistening time was 60 min, with 60% microwave heating for 3 min.

Conclusion: This method is simple, practical, scientific and easy to control.

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