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A systematic review and meta-analysis of the response to placebo in clinical trials of inclusion body myositis.
Rheumatology (Oxford)
March 2025
Mayo Clinic Evidence-based Practice Center, Mayo Clinic, Rochester, MN, USA.
Objectives: Inclusion body myositis (IBM) is characterized by slowly progressive muscle weakness making it challenging to detect weakness changes during a clinical trial. Trial participants receiving placebo may behave differently than in natural history studies. We aimed to quantify the decline in muscle strength and IBM functional rating scale (IBMFRS) of IBM patients receiving placebo during clinical trials.
View Article and Find Full Text PDFPalliative care: a foreign language? Nurses' perspectives on palliative care in a French comprehensive cancer centre.
BMC Palliat Care
March 2025
Département de Soins de Support, IUCT-Oncopole, Oncopole Claudius Regaud, 1 avenue Irène Joliot-Curie, Toulouse Cedex 9, 31059, France.
Background: Integrated patient-centred palliative care for cancer patients is widely advocated internationally, but promoting it often proves difficult. The literature suggests that one key factor is physicians' perspectives of palliative care (PC). Nurses' views, however, from their pivotal stance within the healthcare team between patients and physicians, have been less well researched.
View Article and Find Full Text PDFAssessing Racial and Ethnic Bias in Text Generation by Large Language Models for Health Care-Related Tasks: Cross-Sectional Study.
J Med Internet Res
March 2025
Information Services, ECU Health, Greenville, NC, United States.
Background: Racial and ethnic bias in large language models (LLMs) used for health care tasks is a growing concern, as it may contribute to health disparities. In response, LLM operators implemented safeguards against prompts that are overtly seeking certain biases.
Objective: This study aims to investigate a potential racial and ethnic bias among 4 popular LLMs: GPT-3.
Effects of pyrimidine on cellular and neuronal arrangement, oxidative stress and energy content in the brain of the freshwater catfish, Heteropneustes fossilis.
Fish Physiol Biochem
March 2025
Department of Zoology, Babasaheb Bhimrao Ambedkar University, Raebareli Road, Lucknow, 226025, Uttar Pradesh, India.
Fish are facing compromised health with mass mortality due to the decreased water quality of aquatic bodies. The brain, a complex body organ that controls whole body physiology, is influenced first by any kind of water fluctuations, and by keeping it relaxed and nourished, fish health can be improved. Among freshwater fish, catfish Heteropneustes fossilis has importance not only as a rich nutrient source but also due to medicinal significance.
View Article and Find Full Text PDFProtective and risk factors in daily life associated with cognitive decline of older adults.
Front Aging Neurosci
February 2025
Institute of Wound Prevention and Treatment, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Background: Cognitive decline is a chronic condition which is characterized by a loss of the ability to remember, learn, and pay attention to complex tasks. Many older people are now suffering from cognitive decline, which decreases life quality and leads to disability. This study aimed to identify the risk and protective factors for cognitive decline of the older people from daily life and establish a predictive model using logistic regression.
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