AI Article Synopsis
- The study looked at the endometrial tissue and VEGF expression in women with recurrent miscarriages compared to fertile women.
- In the recurrent miscarriage group, 42% had a luteal phase defect (LPD), while only 13% of the control group had it.
- Lower VEGF mRNA levels were found in LPD endometrium, suggesting that these abnormalities could contribute to difficulties in achieving a successful pregnancy.
Article Abstract
Endometrial morphology and expression of vascular endothelial growth factor (VEGF) was examined in the endometria of women with history of recurrent miscarriage (RM group) and of fertile women without history of gynecological diseases (control group). Luteal phase defect (LPD) was diagnosed in 42% cases in the RM group vs. 13% in controls. Endometrial VEGF mRNA expression was lower in LPD endometria compared to mature endometria. In conclusion, LPD in non-pregnant endometrium is associated with angiogenic abnormalities and may cause pregnancy complications.
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| http://dx.doi.org/10.1016/j.repbio.2014.10.001 | DOI Listing |
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