FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells.

Leukemic stem cells (LSCs) fuel acute myeloid leukemia (AML) growth and relapse, but therapies tailored towards eradicating LSCs without harming normal hematopoietic stem cells (HSCs) are lacking. FLT3 is considered an important therapeutic target due to frequent mutation in AML and association with relapse. However, there has been limited clinical success with FLT3 drug targeting, suggesting either that FLT3 is not a vulnerability in LSC, or that more potent inhibition is required, a scenario where HSC toxicity could become limiting.

Effect of fructo-oligosaccharides on growth performance and meat quality in broilers.

This study investigated the fructo-oligosaccharides (FOS) on growth performance and meat quality in broilers. Total 160 Xianghuang broilers aged 2 months were randomly assigned into 2 groups, CON (control), FOS (supplemented 0.5% fructo-oligosaccharides in diet).

Effects of feeding of vitamin C on embryonic development, hatching process, and chick rectal temperature of broiler embryos.

Maternal nutritional status plays a crucial role in embryonic development and has persistent effects on postnatal chicks. Vitamin C (VC) plays an important role in embryonic and postnatal development involved in nutri-epigenetics. The present study was conducted to investigate the effects of feeding (IOF) of VC on embryonic development, egg hatching time, and chick rectal temperature.

Typhoid Fever as a Cause of Liver Failure in the United States: A Case Report.

Typhoid fever is a multisystemic illness caused by and , transmitted fecal orally through contaminated water and food. It is a rare diagnosis in the US, with most cases reported in returning travelers. Hepatitis and cholestasis are rare sequelae of infection.

Giant Hydatid Cyst Originating From Psoas Muscle Extending to the Iliac Bone: A Case Report.

Hydatid cysts, caused by the parasite, predominantly affect the liver and lungs, but can also impact other organs such as the kidneys, brain, and muscles. Infection occurs when individuals ingest eggs from contaminated food or water, leading to cyst formation primarily in the liver. While hydatid cysts are commonly found in various endemic regions, muscular involvement is rare, particularly in the psoas muscle.