Cognitive training has received a lot of attention recently, yielding findings that can be conflicting and controversial. In this paper, we present a novel approach to cognitive training based on complex motor activities. In a randomized controlled design, participants were assigned to one of three conditions: aerobic exercise, working memory training or designed sport--an intervention specifically tailored to include both physical and cognitive demands. After training for eight weeks, the designed sport group showed the largest gains in all cognitive measures, illustrating the efficacy of complex motor activities to enhance cognition. Designed sport training also revealed impressive health benefits, namely decreased heart rate and blood pressure. In this period of skepticism over the efficacy of computerized cognitive training, we discuss the potential of ecological interventions targeting both cognition and physical fitness, and propose some possible applications.
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http://dx.doi.org/10.1016/j.actpsy.2015.02.007 | DOI Listing |
Science
January 2025
Department of Medicine and Surgery, University of Parma, Parma, Italy.
The current understanding of primate natural action organization derives from laboratory experiments in restrained contexts (RCs) under the assumption that this knowledge generalizes to freely moving contexts (FMCs). In this work, we developed a neurobehavioral platform to enable wireless recording of the same premotor neurons in both RCs and FMCs. Neurons often encoded the same hand and mouth actions differently in RCs and FMCs.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Background: COVID-19, identified as the greatest health concern of the century, is associated with vascular inflammation and endothelial activation, resulting in multisystemic damage, including to the central nervous system (CNS). Recent investigations indicate a link between endothelial dysfunction, neurological changes, and the development of the so-called long-COVID. Molecules expressed in the endothelium such as P-selectin, E-selectin, and VEGF-A, increased under inflammatory injury, may be associated with conditions like brain injuries and neurodegenerative diseases.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Alzheimer's Disease (AD) is a neurodegenerative disease which affects motor-cognitive abilities including handwriting. Past studies have used simple writing tasks to analyze handwriting fluidity, while more complex tasks can detect visual-spatial deficits through spatial organization analysis. In this study, we extracted explainable features from the handwriting of AD patients performing various writing tasks using signal processing techniques and analyzed their importance in the cognitive assessment of AD.
View Article and Find Full Text PDFBackground: With the advent of monoclonal antibody therapy to treat mild cognitive impairment and mild dementia due to Alzheimer's disease (AD) there is a need to develop tests to screen for neurocognitive difficulty that are reliable and easily deployed.
Method: The Rowan Digital Cancellation Tests (RDCT) is comprised of three tests administered using an iPad Pro. Each test was preceded by a practice trial.
Alzheimers Dement
December 2024
University of Kansas Alzheimer's Disease Research Center, Fairway, KS, USA.
Background: A growing amount of data has implicated the various roles of nuclear genes involved in mitochondrial function, and mitochondrial genes, on risk for Alzheimer's disease (AD) and AD neuroimaging biomarkers. To date, no studies have investigated the relationship of mitochondrial haplogroups or the APOE and TOMM40 genes on brain glucose metabolism, a sensitive early marker of metabolic decline and possible mitochondrial dysfunction in AD.
Method: We analyzed regional standard uptake value ratio (SUVR) differences in F-fluorodeoxyglucose positron emission tomography (FDG-PET) using SPM12 and CAT12 software between nondemented (ND, n=69), mild cognitively impaired (MCI, n=19) and AD (n=18) groups in a sample of individuals from the University of Kansas Alzheimer's Disease Research Center Cohort, controlling for age, sex, and education.
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