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Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp. | LitMetric
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Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp.

Jung-Rae Rho Gurusamy Subramaniam Hyukjae Choi Eun-Hee Kim Sok Peng Ng K Yoganathan Siewbee Ng Antony D Buss Mark S Butler William H Gerwick

Org Lett

†Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, United States.

Published: March 2015

Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishi's universal NMR database.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125438PMC
http://dx.doi.org/10.1021/acs.orglett.5b00068DOI Listing

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