AI Article Synopsis
- * Microarray analysis revealed that out of 14,112 detectable genes, 152 showed significant expression changes linked to processes like immunity, cell cycle, and metabolism.
- * Validation through real-time polymerase chain reactions and immunohistochemistry suggests that SV40 large T antigen may activate the insulin-like growth factor pathway, contributing to tumor development in the brain.
Article Abstract
Signaling pathways known to have components with mutations in human medulloblastoma include sonic hedgehog, Wnt/beta-catenin and insulin-like growth factor. Microarray analysis was applied to examine the gene expression changes in medulloblastomas of pTet-on/pTRE-SV40Tag transgenic mice. Altogether, 14 112 genes were detectable, including 152 genes with significantly different expression levels. These genes were associated with immunity, the cell cycle, signal transduction, cytoskeleton and metabolism. To further confirm the microarray data, real-time polymerase chain reactions were used to examine the expression changes of genes related to sonic hedgehog, Wnt/beta-catenin and insulin-like growth factor signal pathways. Immunohistochemistry detected insulin receptor substrate-1 in the nuclei of brain tumor tissue cells from pTet-on/pTRE-SV40Tag transgenic mice, suggesting that SV40 large T antigen may activate the insulin-like growth factor signal pathway to promote tumorigenesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341289 | PMC |
| http://dx.doi.org/10.3969/j.issn.1673-5374.2012.12.009 | DOI Listing |
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