An anaesthetised dog preparation was used to examine the pharmacological profiles of xamoterol, cicloprolol, prenalterol and pindolol. The effects of these agents on heart rate and hind limb perfusion pressure revealed that xamoterol is highly cardioselective and has no significant agonist activity at beta 2-receptors and no membrane stabilising effect. These pharmacological properties are not complicated by the formation of active metabolites and may explain the clinical benefits in the long-term treatment of heart failure.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1379883 | PMC |
| http://dx.doi.org/10.1111/j.1365-2125.1989.tb03580.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The cardiovascular pharmacology of xamoterol, cicloprolol, prenalterol and pindolol in the anaesthetised dog.
Br J Clin Pharmacol
December 1989
ICI Pharmaceuticals, Macclesfield, Cheshire.
An anaesthetised dog preparation was used to examine the pharmacological profiles of xamoterol, cicloprolol, prenalterol and pindolol. The effects of these agents on heart rate and hind limb perfusion pressure revealed that xamoterol is highly cardioselective and has no significant agonist activity at beta 2-receptors and no membrane stabilising effect. These pharmacological properties are not complicated by the formation of active metabolites and may explain the clinical benefits in the long-term treatment of heart failure.
View Article and Find Full Text PDFComparative analysis of beta-1 adrenoceptor agonist and antagonist potency and selectivity of cicloprolol, xamoterol and pindolol.
J Pharmacol Exp Ther
September 1987
Department of Biology, Laboratoires d'Etudes et de Recherches Synthélabo, Paris, France.
The partial beta adrenoceptor agonist properties of cicloprolol, xamoterol and pindolol have been compared in vivo (anesthetized catecholamine-depleted or pithed rats) and in vitro (guinea pig or rat right atria and guinea pig tracheal muscle preparations) conditions. All three compounds increased heart rate in the former preparations, and their intrinsic activities relative to isoproterenol were 0.7, 0.
View Article and Find Full Text PDFA technique is described for screening the effects of inotropic drugs on isolated rat or guinea pig hearts perfused at constant coronary pressure and at a frequency of 6 Hz. Their performances, including function curves, were recorded using an intraventricular balloon. Both preparations became either sensitive from initially having been insensitive, or more sensitive from having been slightly sensitive at the outset, to inotropic interventions, provided the external calcium concentration was reduced to 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!