AI Article Synopsis
- - A 39-year-old man with bipolar disorder was hospitalized for depression and treated with a combination of medications, including quetiapine, which is an antipsychotic.
- - After a week on quetiapine, he experienced severe abdominal pain and constipation; a CT scan showed significant colon distention, leading to surgery for necrotising ischaemic colitis.
- - This case highlights the rare but dangerous potential side effects of quetiapine, especially when combined with tropatepine, an anticholinergic, warning clinicians to be cautious with these medications together.
Article Abstract
A 39-year-old man with bipolar disorder was hospitalised for depression. He was started on quetiapine (titrated up to 300 mg), lactulose (a laxative) and tropatepine (an anticholinergic). Valpromide (a mood stabiliser) and prazepam were later added and rapidly withdrawn. Seven days after quetiapine initiation, the patient reported abdominal pain and constipation; 2 days later, CT revealed an important distention of the colon including the caecum and a pre-perforation. A subtotal colectomy was performed and histology confirmed necrotising ischaemic colitis. The patient survived. This is the first case reported so far of ischaemic colitis related to quetiapine, in the absence of other antipsychotics simultaneously prescribed. Tropatepine likely acted as a cofactor to determine colitis. Clinicians need to be aware of the potential danger of the co-prescription of quetiapine with tropatepine (and possibly other anticholinergics).
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342667 | PMC |
| http://dx.doi.org/10.1136/bcr-2014-207912 | DOI Listing |
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