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Antibody-Based Immunotherapies for the Treatment of Hematologic Malignancies.
Cancers (Basel)
December 2024
Division of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Despite the great advancements in treatment strategies for hematological malignancies (HMs) over the years, their effective treatment remains challenging. Conventional treatment strategies are burdened with several serious drawbacks limiting their effectiveness and safety. Improved understanding of tumor immunobiology has provided novel anti-cancer strategies targeting selected immune response components.
View Article and Find Full Text PDFNodular lymphocyte-predominant Hodgkin lymphoma revisited: current management strategies and future perspectives.
Leuk Lymphoma
January 2025
First Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, University of Cologne, Cologne, Germany.
Article Synopsis
- Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare type of lymphoma, making up about 5% of Hodgkin lymphoma cases, and shares some characteristics with B-cell non-Hodgkin lymphoma.
- NLPHL is typically diagnosed at early stages and has a slow progression, leading to excellent long-term survival rates for most patients.
- Treatment mainly mirrors classical Hodgkin lymphoma but may include rituximab; future strategies could involve innovative therapies like CAR T-cell therapy and bispecific antibodies.
Radiation-induced nephrotoxicity: Role of SMPDL3b.
Int J Radiat Oncol Biol Phys
December 2024
Department of Radiation Oncology, University of Miami, Sylvester Comprehensive Cancer Center/ Miller School of Medicine, Miami, FL, USA; Department of Radiation Oncology, University of Rochester, 601 Elmwood Ave. Box 647 Rochester, NY, USA. Electronic address:
Background: Radiation nephropathy (RN) can be a significant late complication after radiotherapy for abdominal and paraspinal tumors. The mechanisms for the development of RN are thought to involve disruption of podocyte function, leading to podocyte cell death and, finally, impaired renal function. This study investigated the mechanistic role of SMPDL3b in regulating podocyte injury and renal function after irradiation.
View Article and Find Full Text PDFRadiotherapeutic Treatment of an Epidermoid Tumor in a Patient With Zanubrutinib-Treated Mantle Cell Lymphoma: The First Report of Concomitant Treatment.
Cureus
November 2024
Radiation Oncology, Centre intégré de cancérologie (CIC) Hôpital de l'Enfant-Jésus, Centre Hospitalier Universitaire de Québec - Université Laval (CHU de Québec-Université Laval), Québec, CAN.
Mantle cell lymphoma (MCL) is a challenging B-cell non-Hodgkin lymphoma with a poor prognosis and frequent relapses. While treatment advancements such as rituximab and Bruton tyrosine kinase inhibitors (BTKi) like ibrutinib have improved outcomes, novel treatments are continually sought. Zanubrutinib, a second-generation BTKi, promises reduced side effects due to its high selectivity and reduced off-target inhibition.
View Article and Find Full Text PDFA Rare Case of Diffuse Large B-cell Lymphoma in the Breast: Diagnostic Insights and Treatment Approaches.
Cureus
November 2024
Hematology, Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, MAR.
Diffuse large B-cell lymphoma (DLBCL) is a rare and aggressive form of non-Hodgkin lymphoma (NHL) that can occur in the breast. This case report details the case of a 48-year-old postmenopausal woman diagnosed with primary breast DLBCL after presenting with a painless, rapidly growing mass. Imaging studies, including ultrasound and mammography, indicated significant breast involvement, confirmed by histopathological analysis revealing large atypical lymphoid cells.
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