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| http://dx.doi.org/10.2807/1560-7917.es2015.20.7.21038 | DOI Listing |
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A whole-body imaging technique for tumor-specific diagnostics and screening of B7-H3-targeted therapies.
J Clin Invest
January 2025
Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China.
Background: B7-H3 or CD276 is notably overexpressed in various malignant tumor cells in humans, with extremely high expression rates. The development of a radiotracer that targets B7-H3 may provide a universal tumor-specific imaging agent and allow the noninvasive assessment of the whole-body distribution of B7-H3-expressing lesions.
Methods: We enhanced and optimized the structure of an affibody (ABY) that targets B7-H3 to create the radiolabeled radiotracer [68Ga]Ga-B7H3-BCH, and then, we conducted both foundational experiments and clinical translational studies.
A Novel Artificial Intelligence-Enhanced Digital Network for Prehospital Emergency Support: Community Intervention Study.
J Med Internet Res
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Department of Cardiology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Background: Efficient emergency patient transport systems, which are crucial for delivering timely medical care to individuals in critical situations, face certain challenges. To address this, CONNECT-AI (CONnected Network for EMS Comprehensive Technical-Support using Artificial Intelligence), a novel digital platform, was introduced. This artificial intelligence (AI)-based network provides comprehensive technical support for the real-time sharing of medical information at the prehospital stage.
View Article and Find Full Text PDFSign Language Recognition System for Deaf Patients: Protocol for a Systematic Review.
JMIR Res Protoc
January 2025
Department of Computer Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Background: Individuals with hearing impairments may face hindrances in health care assistance, which may significantly impact the prognosis and the incidence of complications and iatrogenic events. Therefore, the development of automatic communication systems to assist the interaction between this population and health care workers is paramount.
Objective: This study aims to systematically review the evidence on communication systems using human-computer interaction techniques developed for deaf people who communicate through sign language that are already in use or proposed for use in health care contexts and have been tested with human users or videos of human users.
Identification of genetic variants of the gene in association with COPD susceptibility.
Ann Med
December 2025
Department of General Practice, Hainan affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, China.
Background: Although existing studies have identified some genetic loci associated with chronic obstructive pulmonary disease (COPD) susceptibility, many variants remain to be discovered. The aim of this study was to further explore the potential relationship between single nucleotide polymorphisms (SNPs) and COPD risk.
Methods: Nine hundred and ninety-six subjects were recruited (498 COPD cases and 498 healthy controls).
WHO Disability Assessment Schedule 2.0: responsiveness in detecting long-term functional disability after surgery.
Br J Surg
December 2024
Department of Anaesthesiology, Nara Medical University, Nara, Japan.
Background: The WHO Disability Assessment Schedule (WHODAS) 2.0 is widely used for detecting postoperative functional disability. Its responsiveness for detecting disability has been evaluated at 1 year after surgery, with no long-term evaluation.
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