AI Article Synopsis
- The study analyzed how the Y chromosome affects testis weight in specific mouse strains and found that those with a Mus musculus domesticus-type Y chromosome had heavier testis compared to those with a M. m. musculus-type Y chromosome.
- Key genetic factors, including variations in the Usp9y gene and the number of CAG repeats in the Sry gene, were linked to testis weight, with the A(y) allele being associated with lower testis weight.
- The findings indicate that genes located on the Y chromosome not only play a role in determining testis weight but also interact with the A(y) allele to impact this weight.
Article Abstract
We investigated the effect of the Y chromosome on testis weight in (B6.Cg-A(y) × Y-consomic mouse strain) F1 male mice. We obtained the following results: (1) Mice with the Mus musculus domesticus-type Y chromosome had significantly heavier testis than those with the M. m. musculus-type Y chromosome. (2) Variations in Usp9y and the number of CAG repeats in Sry were significantly associated with testes weight. The A(y) allele was correlated with a reduced testis weight, and the extent of this reduction was significantly associated with a CAG repeat number polymorphism in Sry. These results suggest that Y chromosome genes not only influence testis weight but also modify the effect of the A(y) allele in mediating this phenomenon.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488418 | PMC |
| http://dx.doi.org/10.1292/jvms.14-0423 | DOI Listing |
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