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Lipophagy and Alcohol-Induced Fatty Liver.
Front Pharmacol
May 2019
Research Service, Department of Veterans Affairs, Nebraska-Western Iowa Health Care System, Omaha, NE, United States.
This review describes the influence of ethanol consumption on hepatic lipophagy, a selective form of autophagy during which fat-storing organelles known as lipid droplets (LDs) are degraded in lysosomes. During classical autophagy, also known as macroautophagy, all forms of macromolecules and organelles are sequestered in autophagosomes, which, with their cargo, fuse with lysosomes, forming autolysosomes in which the cargo is degraded. It is well established that excessive drinking accelerates intrahepatic lipid biosynthesis, enhances uptake of fatty acids by the liver from the plasma and impairs hepatic secretion of lipoproteins.
View Article and Find Full Text PDFPreventive lipostasis: spawning lipochondria.
Indian J Med Ethics
December 2016
Professor (Retired), Department of Anatomy, Seth GS Medical College and KEM Hospital, Parel, Mumbai 400 012 India.
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