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http://dx.doi.org/10.1590/2176-9451.19.5.031-043.int | DOI Listing |
Eur J Cancer
July 2021
Cancer Medicine Department, Gustave Roussy, Villejuif, France; University Paris-Saclay, School of Medicine, France. Electronic address:
Background: dNLR at the baseline (B), defined by neutrophils/[leucocytes-neutrophils], correlates with immune-checkpoint inhibitor (ICI) outcomes in advanced non-small-cell lung cancer (aNSCLC). However, dNLR is dynamic under therapy and its longitudinal assessment may provide data predicting efficacy. We sought to examine the impact of dNLR dynamics on ICI efficacy and understand its biological significance.
View Article and Find Full Text PDFEur J Cancer
March 2021
Pathology Department, Gustave Roussy, Villejuif, France. Electronic address:
Background: The established role of morphological evaluation of tumour-infiltrating lymphocytes (TILs) with immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC) is unknown. We aimed to determine TIL association with the outcome for ICIs and for chemotherapy in advanced NSCLC.
Methods: This is a multicenter retrospective study of a nivolumab cohort of 221 patients treated between November 2012 and February 2017 and a chemotherapy cohort of 189 patients treated between June 2009 and October 2016.
Cancers (Basel)
September 2020
Cancer Medicine Department, Gustave Roussy, 94805 Villejuif, France.
Background: Baseline steroids before ICI have been associated with poor outcomes, particularly when introduced due to cancer symptoms.
Methods: Retrospective analysis of advanced NSCLC patients treated with ICI. We collected the use of intercurrent steroids (≥10 mg of prednisone-equivalent) within the first eight weeks of ICI.
Sex Health
November 2012
Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Background: Although jail screening programs have an important role in the diagnosis and treatment of sexually transmissible infections (STI) and HIV among incarcerated individuals, many arrestees are not screened before release. Justice-involved women are at particularly high risk for these conditions because of individual risk behaviour as well as other network-level risk factors. Court-based programs could provide a critical bridge between these women, STI risk counselling and health services.
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