The article contains an analysis of the current state of the problem of retinopathy of prematurity (RP). Advances of international and Russian ophthalmology in understanding the pathogenesis, clinical presentation of both active and regressive RP, results of multicentre studies on RP treatment and prognosis were taken into consideration. There is a tendency towards a considerable change in the range of survived premature newborns and a growing need for development of new treatment approaches on the basis of pathogenetic studies. A wide range of RP outcomes, late complications, and concomitant pathology, which determine functional prognosis and quality of life in patients who have had RP, is discussed.
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Intell Based Med
July 2024
School of Industrial Engineering and Management, Oklahoma State University, Stillwater, OK, USA.
Objective: The paper aims to address the problem of massive unlabeled patients in electronic health records (EHR) who potentially have undiagnosed diabetic retinopathy (DR). It is desired to estimate the actual DR prevalence in EHR with 96 % missing labels.
Materials And Methods: The Cerner Health Facts data are used in the study, with 3749 labeled DR patients and 97,876 unlabeled diabetic patients.
Stem Cell Res Ther
December 2024
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.
Background: Mesenchymal stem cells may have neuroprotective and tissue regenerative capabilities and the potential to rescue retinal degeneration in chorioretinal diseases including myopic chorioretinal atrophy. Transplantation of human (allogeneic) adipose tissue-derived mesenchymal stem cell (adMSC) suspensions has been clinically conducted to treat retinal degenerative diseases. However, serious side effects including proliferative vitreoretinopathy and epiretinal membrane formation have been reported.
View Article and Find Full Text PDFJ Clin Med
November 2024
Department of Second Internal Medicine Diabetes, Nutrition, Metabolic Diseases, and Systemic Rheumatology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Diabetes mellitus (DM) is one of the most impactful health problems worldwide. It affects ocular health in multiple ways and is one of the leading causes of vision loss. Our study aimed to evaluate the most important systemic risk factors related to the occurrence of cataracts in patients with DM.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Drug Sciences, Section of Pharmacology, University of Pavia, 27100 Pavia, Italy.
Age-related macular degeneration (AMD) is the most common cause of irreversible loss of central vision in elderly subjects, affecting men and women equally. It is a degenerative pathology that causes progressive damage to the macula, the central and most vital part of the retina. There are two forms of AMD depending on how the macula is damaged, dry AMD and wet or neovascular AMD.
View Article and Find Full Text PDFPediatr Res
December 2024
Division of Newborn Medicine, Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA.
Artificial intelligence (AI) is a rapidly advancing area with growing clinical applications in healthcare. The neonatal intensive care unit (NICU) produces large amounts of multidimensional data allowing AI and machine learning (ML) new avenues to improve early diagnosis, enhance monitoring, and provide highly-targeted treatment approaches. In this article, we review recent clinical applications of AI to important neonatal problems, including sepsis, retinopathy of prematurity, bronchopulmonary dysplasia, and others.
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