Cannabinoids disrupt learning and memory in human and nonhuman participants. Object recognition memory, which is particularly susceptible to the impairing effects of cannabinoids, relies critically on the perirhinal cortex (PRh); however, to date, the effects of cannabinoids within PRh have not been assessed. In the present study, we evaluated the effects of localized administration of the synthetic cannabinoid, HU210 (0.01, 1.0 μg/hemisphere), into PRh on spontaneous object recognition in Long-Evans rats. Animals received intra-PRh infusions of HU210 before the sample phase, and object recognition memory was assessed at various delays in a subsequent retention test. We found that presample intra-PRh HU210 dose dependently (1.0 μg but not 0.01 μg) interfered with spontaneous object recognition performance, exerting an apparently more pronounced effect when memory demands were increased. These novel findings show that cannabinoid agonists in PRh disrupt object recognition memory.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/WNR.0000000000000338 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Human-like face pareidolia emerges in deep neural networks optimized for face and object recognition.
PLoS Comput Biol
January 2025
Department of Experimental Psychology, Justus Liebig University Giessen, Giessen, Germany.
The human visual system possesses a remarkable ability to detect and process faces across diverse contexts, including the phenomenon of face pareidolia--seeing faces in inanimate objects. Despite extensive research, it remains unclear why the visual system employs such broadly tuned face detection capabilities. We hypothesized that face pareidolia results from the visual system's optimization for recognizing both faces and objects.
View Article and Find Full Text PDFThe potential of alphapinene as a therapeutic agent for maternal hypoxia-induced cognitive impairments: a study on HO-1 and Nrf2 gene expression in rats.
Metab Brain Dis
January 2025
Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
This research seeks to address the gap in past studies by examining the role of the Nrf2 (nuclear factor erythroid 2-related factor 2) and HO-1 (heme oxygenase-1) signaling pathways in hypoxia and the potential effects of alpha-pinene on these factors. Wistar rats were divided into 7 experimental groups (n = 7): 1) control, 2 and 3) groups receiving alpha-pinene 5 and 10 mg/kg (i.p.
View Article and Find Full Text PDFAssessing the readability, quality and reliability of responses produced by ChatGPT, Gemini, and Perplexity regarding most frequently asked keywords about low back pain.
PeerJ
January 2025
Anesthesiology and Reanimation, Central Clinical Hospital, Baku, Azerbaijan.
Background: Patients who are informed about the causes, pathophysiology, treatment and prevention of a disease are better able to participate in treatment procedures in the event of illness. Artificial intelligence (AI), which has gained popularity in recent years, is defined as the study of algorithms that provide machines with the ability to reason and perform cognitive functions, including object and word recognition, problem solving and decision making. This study aimed to examine the readability, reliability and quality of responses to frequently asked keywords about low back pain (LBP) given by three different AI-based chatbots (ChatGPT, Perplexity and Gemini), which are popular applications in online information presentation today.
View Article and Find Full Text PDFCytoplasmic expression of trans-active response DNA-binding protein-43 in aged mice display hippocampal sclerosis-like degeneration and neuronal loss with reduced lifespan.
J Neuropathol Exp Neurol
January 2025
Department of Biological Sciences, Delaware State University, Dover, DE, United States.
Trans-active response DNA-binding protein-43 (TDP-43) is the major pathological protein in motor neuron disease and TDP-43 pathology has been described in the brains of up to 50% of patients with Alzheimer disease (AD). Hippocampal sclerosis of aging (HS-A), an age-related neuropathology characterized by severe neuronal loss and gliosis in CA1 and/or subiculum, is found in ∼80% of cases that are positive for phosphorylated TDP-43. HS-A is seen as a co-pathology in cases with AD, limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC), and frontotemporal degeneration.
View Article and Find Full Text PDFImproved particle filter algorithm combined with culture algorithm for collision Caenorhabditis elegans tracking.
Sci Rep
January 2025
Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, China.
In order to address the issue of tracking errors of collision Caenorhabditis elegans, this research proposes an improved particle filter tracking method integrated with cultural algorithm. The particle filter algorithm is enhanced through the integration of the sine cosine algorithm, thereby facilitating uninterrupted tracking of the target C. elegans.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!