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Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool. | LitMetric
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Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool.

Andrea Trochine Darren J Creek Paula Faral-Tello Michael P Barrett Carlos Robello

Antimicrob Agents Chemother

Unidad de Biología Molecular, Institut Pasteur de Montevideo, Montevideo, Uruguay Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

Published: May 2015

Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394807PMC
http://dx.doi.org/10.1128/AAC.05046-14DOI Listing

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