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| http://dx.doi.org/10.1111/bcp.12605 | DOI Listing |
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Commentary: The prodigal son returns.
J Thorac Cardiovasc Surg
April 2022
Department of Cardiac Surgery, Vanderbilt University Medical Center, Vanderbilt Medical Center East, Nashville, Tenn. Electronic address:
Alcohol and the Liver: The Return of the Prodigal Son.
Ann Hepatol
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Center of Studies on Alcohol and Addictions, Hospital Civil de Guadalajara FAA, Universidad de Guadalajara. Guadalajara, Jalisco, Mexico. Electronic address:
With the discovery of direct-acting antivirals and the prospective of viral hepatitis becoming curable, alcohol liver disease (ALD) is back to primetime. In the last 20 years, there have been many advances in the understanding of the biology, the psychology and the social and environmental factors associated with this long-known medical problem. Recent information about regional, ethnic, cultural and genetic factors seem to be relevant for the Latin American (LA) population.
View Article and Find Full Text PDFThe Prodigal Compound: Return of Ribosyl 1,5-Bisphosphate as an Important Player in Metabolism.
Microbiol Mol Biol Rev
March 2019
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Ribosyl 1,5-bisphosphate (PRibP) was discovered 65 years ago and was believed to be an important intermediate in ribonucleotide metabolism, a role immediately taken over by its "big brother" phosphoribosyldiphosphate. Only recently has PRibP come back into focus as an important player in the metabolism of ribonucleotides with the discovery of the pentose bisphosphate pathway that comprises, among others, the intermediates PRibP and ribulose 1,5-bisphosphate (cf. ribose 5-phosphate and ribulose 5-phosphate of the pentose phosphate pathway).
View Article and Find Full Text PDFI use an individual-based model to investigate the evolution of cell division rates in asexual populations under chronic environmental enrichment. I show that maintaining increased growth rates over hundreds of generations following environmental improvement can be limited by increases in cellular damage associated with more rapid reproduction. In the absence of further evolution to either increase damage tolerance or decrease the cost of repair or rate of damage, environmental improvement does not reliably lead to long-term increases in reproductive rate in microbes.
View Article and Find Full Text PDFMethotrexate in IBD: the return of the prodigal son.
J Crohns Colitis
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Service de Gastroentérologie, Hôpital universitaire de Bicêtre, Université Paris Sud, Assistance Publique-Hôpitaux de Paris, le Kremlin Bicêtre, Paris, France.
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