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Intestinal neutrophil extracellular traps promote gut barrier damage exacerbating endotoxaemia, systemic inflammation and progression of diabetic retinopathy in type 2 diabetes.
Diabetologia
January 2025
Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Aims/hypothesis: Within the small intestine, neutrophils play an integral role in preventing bacterial infection. Upon interaction with bacteria or bacteria-derived antigens, neutrophils initiate a multi-staged response of which the terminal stage is NETosis, formation of protease-decorated nuclear DNA into extracellular traps. NETosis has a great propensity to elicit ocular damage and has been associated with diabetic retinopathy and diabetic macular oedema (DME) progression.
View Article and Find Full Text PDFConservative Reconstruction of the Lower Limb with a Bilayer Porous Collagen Matrix after a Spider Bite.
Adv Skin Wound Care
January 2025
Marco Palmesano, MD, is Plastic Reconstructive and Aesthetic Surgeon, PhD Program in Applied Medical Surgical Sciences, University of Rome Tor Vergata, Rome, Italy. Davide Johan Bottini, MD, PhD, is Consultant in Maxillofacial Surgery, Policlinico Casilino Hospital, Rome. Also at University of Rome Tor Vergata, Gabriele Storti, MD, is Researcher and Consultant in Plastic Surgery; Lorenzo Secondi, MD, is Plastic Reconstructive and Aesthetic Surgeon, PhD Program in Applied Medical Surgical Sciences; and Carlo Cossi, MD; Alessio Calicchia, MD; Martina Giacalone, MD; and Irene Nunziata, MD, are Plastic Surgery Residents. Emanuela Basile, MD, is Consultant in Maxillofacial Surgery, Policlinico Casilino Hospital. Valerio Cervelli, MD, is Full Professor and Chief, Department of Plastic Surgery, University of Rome Tor Vergata.
Brown recluse spider bites may cause symptoms ranging from local cutaneous reactions to systemic visceral loxoscelism. Most bites are self-limiting, but some can lead to necrotic ulcerations with severe complications and soft tissue defects. Necrotizing ulcers are uncommon and have various clinical presentations, so no standard treatment exists.
View Article and Find Full Text PDFMicrocirculatory depth of focus measurement shows reduction of tissue edema by albumin resuscitation in burn patients.
J Intensive Med
January 2025
Association of Dutch Burn Centres, Burn Centre Maasstad Hospital, Rotterdam, the Netherlands.
Background: Severe burns induce volume shifts via capillary leaks, eventually requiring massive fluid resuscitation and promoting tissue edema. Albumin may help to mitigate the edema, thereby improving perfusion. This study shows that sublingual microcirculation measurements can quantify both tissue perfusion and edema.
View Article and Find Full Text PDFEvaluation of a modified sutureless technique for scleral fixation of one-piece posterior chamber intraocular lens: a retrospective study.
Front Med (Lausanne)
January 2025
Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: This study presents the one-year outcomes of a modified technique for transscleral suture fixation of a posterior chamber intraocular lens (PCIOL) in aphakic eyes.
Methods: A retrospective chart review was conducted on 45 patients who underwent transscleral suture fixation of a foldable one-piece PCIOL through scleral pockets. Preoperative data and follow-up data for a minimum of 12 months were collected for all patients.
Background: Occurrence of life-threatening scorpion sting in adults is a rare entity compared with children. Different cases of organ failure following scorpion sting have been reported but complications, such as acute toxic myocarditis, cardiogenic shock, pulmonary edema, acute kidney injury and toxic hepatitis occurring simultaneously in adult patients is exceedingly rare with no prior documented similar report. This case report explores the unique presentation of these complications occurring simultaneously and their management in resource limited setting.
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