We investigated the possibility to classify data from patients with different psychiatric disorders on the base of physiological measures of the brain activity. Event-related potentials during the execution of GO/NOGO task were recorded from age matched groups of patients with schizophrenia, major depression and obsessive-compulsive disorder. Separation of independent components for event-related potentials was performed by applying Independent Component Analysis method. Picked out components were used in the method of discriminant analysis to classify the data according to clinical diagnosis. Discriminant analysis of components for event-related potentials allows classifying the data of patients with a suitable amount of matches with an established diagnosis.
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Background: Understanding the genetic etiology of Alzheimer's disease (AD) has been a major focus of research in neurodegenerative diseases. Amid the three common allelic variants of the apolipoprotein E (APOE) gene in humans, called APOE ε2, ε3 and ε4, the ε4 allele is the most common genetic risk factor for late-onset AD, being found in 20% of the world population.
Method: We used Event-Related Potentials (ERP) and Event-Related Spectral Perturbation (ERSP) as features for classification of apolipoprotein E ϵ4 (APOE ε4) allele carriers in AD patients and healthy controls.
Alzheimers Dement
December 2024
Adult Neurodevelopment and Geriatric Psychiatry Division, CAMH, Toronto, ON, Canada.
Background: Previous literature has identified slowing of resting state electroencephalography (EEG) rhythm and abnormal cortical excitation in Alzheimer's Dementia (AD). However, the relationship between these two divergent functional abnormalities and cognitive symptoms of AD are not well understood.
Method: Resting state EEG signal was recorded in participants with AD and HCs for 5 minutes with eyes closed.
Alzheimers Dement
December 2024
Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Background: Cortical excitability is elevated in Alzheimer's disease (AD). Transcranial magnetic stimulation-evoked responses on electromyography (EMG) and electroencephalography (EEG) have captured this increased excitability in motor brain regions. However, it is not yet known if increased excitability is also present in the parietal lobe or the extent to which excitability is related to cognition.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Peking University Institute of Mental Health (Sixth Hospital), Beijing, China.
Background: Individuals with mild cognitive impairment (MCI) have decreased cognitive function, which makes them prone to making inappropriate decisions in complex and uncertain situations. However, there is currently no study being undertaken to investigate the potential neural mechanisms for processing decision-making feedback in MCI patients. The present study aimed to explore the potential neural correlates during feedback evaluation during decision-making under risk and ambiguity in MCI.
View Article and Find Full Text PDFBackground: We have recently reported on the use of Event-Related Potentials (ERP) biomarkers to separate Amyloid PET positive vs Amyloid PET negative patients with mild cognitive impairment (MCI) and dementia. A large body of evidence shows that low levels of beta amyloid and increased tau in the CSF are highly correlated with Alzheimer's pathology in the brain. We investigated the correlation between amyloid and tau in the CSF, and ERP responses in patients with MCI and dementia.
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